A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma
Abstract Background To investigate whether the relative computed tomography (CT) value (rCT) of adjacent pancreatic parenchyma can distinguish focal‐type autoimmune pancreatitis (fAIP) from pancreatic ductal adenocarcinoma (PDAC). Methods A total of 13 patients with fAIP and 20 patients with PDAC we...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2526 |
| _version_ | 1819172146571640832 |
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| author | Chaobin He Dailin Rong Wanming Hu Qian Cai Qiuxia Yang Yize Mao Rong Zhang Shengping Li Yanchun Lv |
| author_facet | Chaobin He Dailin Rong Wanming Hu Qian Cai Qiuxia Yang Yize Mao Rong Zhang Shengping Li Yanchun Lv |
| author_sort | Chaobin He |
| collection | DOAJ |
| description | Abstract Background To investigate whether the relative computed tomography (CT) value (rCT) of adjacent pancreatic parenchyma can distinguish focal‐type autoimmune pancreatitis (fAIP) from pancreatic ductal adenocarcinoma (PDAC). Methods A total of 13 patients with fAIP and 20 patients with PDAC were included in this study. The rCT was calculated as the ratio of the CT value of adjacent pancreatic parenchyma to that of muscle. The diagnostic performance of rCT for discriminating fAIP from PDAC was evaluated using receiver operating characteristic (ROC) analysis. Results Both fAIP and PDAC presented hyper‐fibrosis histologically and delayed enhancement on CT examination. Moreover, the pancreatic parenchyma of fAIP presented serious inflammation. The mean rCT of the parenchyma was significantly lower in fAIP than in PDAC in all phases. The best diagnostic performance of the rCT value was found in the pancreatic phase, with an area under the ROC curve of 0.912, while the areas under the ROC curve of the portal and delayed phases were 0.812 and 0.754, respectively. The optimal cut‐off value for distinguishing fAIP from PDAC was 1.62 in the pancreatic phase. Conclusions The rCT of the pancreatic parenchyma during the pancreatic phase may be a feasible CT feature for differentiating fAIP from PDAC. |
| first_indexed | 2024-12-22T20:02:33Z |
| format | Article |
| id | doaj.art-d8fae4025f984e549aa98bbe87a5ebe2 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-22T20:02:33Z |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-d8fae4025f984e549aa98bbe87a5ebe22022-12-21T18:14:15ZengWileyCancer Medicine2045-76342019-10-018146250625710.1002/cam4.2526A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinomaChaobin He0Dailin Rong1Wanming Hu2Qian Cai3Qiuxia Yang4Yize Mao5Rong Zhang6Shengping Li7Yanchun Lv8State Key Laboratory of Oncology in South China Department of Pancreatobiliary Surgery Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Radiology The Third Affiliated Hospital Sun Yat‐sen University (SYSU) Guangzhou Guangdong ChinaState Key Laboratory of Oncology in South China Department of Pathology Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China Department of Radiology Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China Department of Radiology Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China Department of Pancreatobiliary Surgery Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China Department of Radiology Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China Department of Pancreatobiliary Surgery Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oncology in South China Department of Radiology Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaAbstract Background To investigate whether the relative computed tomography (CT) value (rCT) of adjacent pancreatic parenchyma can distinguish focal‐type autoimmune pancreatitis (fAIP) from pancreatic ductal adenocarcinoma (PDAC). Methods A total of 13 patients with fAIP and 20 patients with PDAC were included in this study. The rCT was calculated as the ratio of the CT value of adjacent pancreatic parenchyma to that of muscle. The diagnostic performance of rCT for discriminating fAIP from PDAC was evaluated using receiver operating characteristic (ROC) analysis. Results Both fAIP and PDAC presented hyper‐fibrosis histologically and delayed enhancement on CT examination. Moreover, the pancreatic parenchyma of fAIP presented serious inflammation. The mean rCT of the parenchyma was significantly lower in fAIP than in PDAC in all phases. The best diagnostic performance of the rCT value was found in the pancreatic phase, with an area under the ROC curve of 0.912, while the areas under the ROC curve of the portal and delayed phases were 0.812 and 0.754, respectively. The optimal cut‐off value for distinguishing fAIP from PDAC was 1.62 in the pancreatic phase. Conclusions The rCT of the pancreatic parenchyma during the pancreatic phase may be a feasible CT feature for differentiating fAIP from PDAC.https://doi.org/10.1002/cam4.2526autoimmune pancreatitiscomputed tomographypancreatic ductal adenocarcinoma |
| spellingShingle | Chaobin He Dailin Rong Wanming Hu Qian Cai Qiuxia Yang Yize Mao Rong Zhang Shengping Li Yanchun Lv A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma Cancer Medicine autoimmune pancreatitis computed tomography pancreatic ductal adenocarcinoma |
| title | A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma |
| title_full | A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma |
| title_fullStr | A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma |
| title_full_unstemmed | A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma |
| title_short | A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma |
| title_sort | feasible ct feature to differentiate focal type autoimmune pancreatitis from pancreatic ductal adenocarcinoma |
| topic | autoimmune pancreatitis computed tomography pancreatic ductal adenocarcinoma |
| url | https://doi.org/10.1002/cam4.2526 |
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