Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
Aggregation of α-Synuclein, possibly caused by disturbance of proteostasis, has been identified as a common pathological feature of Parkinson’s disease (PD). However, the initiating events of aggregation have not been fully illustrated, and this knowledge may be critical to understanding the disease...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00045/full |
| _version_ | 1811290041553518592 |
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| author | Deqiang Han Deqiang Han Deqiang Han Wei Zheng Wei Zheng Wei Zheng Xueyao Wang Xueyao Wang Xueyao Wang Zhiguo Chen Zhiguo Chen Zhiguo Chen |
| author_facet | Deqiang Han Deqiang Han Deqiang Han Wei Zheng Wei Zheng Wei Zheng Xueyao Wang Xueyao Wang Xueyao Wang Zhiguo Chen Zhiguo Chen Zhiguo Chen |
| author_sort | Deqiang Han |
| collection | DOAJ |
| description | Aggregation of α-Synuclein, possibly caused by disturbance of proteostasis, has been identified as a common pathological feature of Parkinson’s disease (PD). However, the initiating events of aggregation have not been fully illustrated, and this knowledge may be critical to understanding the disease mechanisms of PD. Proteostasis is essential in maintaining normal cellular metabolic functions, which regulate the synthesis, folding, trafficking, and degradation of proteins. The toxicity of the aggregating proteins is dramatically influenced by its physical and physiological status. Genetic mutations may also affect the metastable phase transition of proteins. In addition, neuroinflammation, as well as lipid metabolism and its interaction with α-Synuclein, are likely to contribute to the pathogenesis of PD. In this review article, we will highlight recent progress regarding α-Synuclein proteostasis in the context of PD. We will also discuss how the phase transition status of α-Synuclein could correlate with different functional consequences in PD. |
| first_indexed | 2024-04-13T04:06:00Z |
| format | Article |
| id | doaj.art-d8faebbd79ae4641b04a982a5696e961 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-13T04:06:00Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-d8faebbd79ae4641b04a982a5696e9612022-12-22T03:03:20ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-03-011410.3389/fncel.2020.00045500174Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s DiseaseDeqiang Han0Deqiang Han1Deqiang Han2Wei Zheng3Wei Zheng4Wei Zheng5Xueyao Wang6Xueyao Wang7Xueyao Wang8Zhiguo Chen9Zhiguo Chen10Zhiguo Chen11Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Cell Therapy Center, National Clinical Research Center for Geriatric Diseases, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaCenter of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, ChinaKey Laboratory of Neurodegenerative Diseases, Ministry of Education, Cell Therapy Center, National Clinical Research Center for Geriatric Diseases, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaCenter of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, ChinaKey Laboratory of Neurodegenerative Diseases, Ministry of Education, Cell Therapy Center, National Clinical Research Center for Geriatric Diseases, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaCenter of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, ChinaKey Laboratory of Neurodegenerative Diseases, Ministry of Education, Cell Therapy Center, National Clinical Research Center for Geriatric Diseases, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaCenter of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, ChinaAggregation of α-Synuclein, possibly caused by disturbance of proteostasis, has been identified as a common pathological feature of Parkinson’s disease (PD). However, the initiating events of aggregation have not been fully illustrated, and this knowledge may be critical to understanding the disease mechanisms of PD. Proteostasis is essential in maintaining normal cellular metabolic functions, which regulate the synthesis, folding, trafficking, and degradation of proteins. The toxicity of the aggregating proteins is dramatically influenced by its physical and physiological status. Genetic mutations may also affect the metastable phase transition of proteins. In addition, neuroinflammation, as well as lipid metabolism and its interaction with α-Synuclein, are likely to contribute to the pathogenesis of PD. In this review article, we will highlight recent progress regarding α-Synuclein proteostasis in the context of PD. We will also discuss how the phase transition status of α-Synuclein could correlate with different functional consequences in PD.https://www.frontiersin.org/article/10.3389/fncel.2020.00045/fullα-synucleinphase transitionParkinson’s diseaseproteostasisgenetic mutationsinflammation |
| spellingShingle | Deqiang Han Deqiang Han Deqiang Han Wei Zheng Wei Zheng Wei Zheng Xueyao Wang Xueyao Wang Xueyao Wang Zhiguo Chen Zhiguo Chen Zhiguo Chen Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease Frontiers in Cellular Neuroscience α-synuclein phase transition Parkinson’s disease proteostasis genetic mutations inflammation |
| title | Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease |
| title_full | Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease |
| title_fullStr | Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease |
| title_full_unstemmed | Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease |
| title_short | Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease |
| title_sort | proteostasis of α synuclein and its role in the pathogenesis of parkinson s disease |
| topic | α-synuclein phase transition Parkinson’s disease proteostasis genetic mutations inflammation |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.00045/full |
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