Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy
AIM: To observe pathological changes of blood glucose, the retina and pancreatic tissue after establishing rats diabetic retinopathy(DR)model, and preliminary evaluate of Shuangdanmingmu capsule on the improvement of retina and pancreas tissue structure. <p>METHODS: DR rats were fed with Shuan...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-11-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2014/11/201411007.pdf |
| _version_ | 1818552017769988096 |
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| author | Yu-Hui Qin Wen-Juan Li Xi Zhang Zong-Shun Dai Xiao-Liu Chen Ya-Sha Zhou Yan-Jun Ling Bing Zheng |
| author_facet | Yu-Hui Qin Wen-Juan Li Xi Zhang Zong-Shun Dai Xiao-Liu Chen Ya-Sha Zhou Yan-Jun Ling Bing Zheng |
| author_sort | Yu-Hui Qin |
| collection | DOAJ |
| description | AIM: To observe pathological changes of blood glucose, the retina and pancreatic tissue after establishing rats diabetic retinopathy(DR)model, and preliminary evaluate of Shuangdanmingmu capsule on the improvement of retina and pancreas tissue structure. <p>METHODS: DR rats were fed with Shuangdanmingmu capsule. Then the blood glucose and glycated hemoglobin were determined. Immunohitochemical staining was used to observe the expression of structure of retino and pancreas.<p>RESULTS: Compared with the control group, the blood glucose and glycates hemoglobin in Shuangdanmingmu group were decreased after 2mo of treatment(<i>P</i><0.01). The layers tissue of retina was less edema and gradually arranged in Shuangdanmingmu group. The structure of pancreas was clear basically. Fat cells, infiltrati on of lymphocytes and fibrosis hyperplasia appeared in the interacinar and interlobular connective tissue. Some acinar and islet cells of fatty rat pancreatic tissue had fatty or vesicular degeneration.<p>CONCLUSION: Shuangdanmingmu capsule can decrease blood glucose and glycates hemoglobin in DR rats effectively and improve the ultrastructure of retina and pancreas tissue. |
| first_indexed | 2024-12-12T09:07:36Z |
| format | Article |
| id | doaj.art-d8fc54e452254f0599b9a60d1d5a0377 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-12T09:07:36Z |
| publishDate | 2014-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-d8fc54e452254f0599b9a60d1d5a03772022-12-22T00:29:38ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232014-11-0114111943194510.3980/j.issn.1672-5123.2014.11.07Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathyYu-Hui Qin0Wen-Juan Li1Xi Zhang2Zong-Shun Dai3Xiao-Liu Chen4Ya-Sha Zhou5Yan-Jun Ling6Bing Zheng7Hunan Academy of Traditional Chinese Medicine, Changsha 410006, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410007, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410007, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410007, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410007, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410007, Hunan Province, ChinaHunan Academy of Traditional Chinese Medicine, Changsha 410006, Hunan Province, ChinaHunan Academy of Traditional Chinese Medicine, Changsha 410006, Hunan Province, ChinaAIM: To observe pathological changes of blood glucose, the retina and pancreatic tissue after establishing rats diabetic retinopathy(DR)model, and preliminary evaluate of Shuangdanmingmu capsule on the improvement of retina and pancreas tissue structure. <p>METHODS: DR rats were fed with Shuangdanmingmu capsule. Then the blood glucose and glycated hemoglobin were determined. Immunohitochemical staining was used to observe the expression of structure of retino and pancreas.<p>RESULTS: Compared with the control group, the blood glucose and glycates hemoglobin in Shuangdanmingmu group were decreased after 2mo of treatment(<i>P</i><0.01). The layers tissue of retina was less edema and gradually arranged in Shuangdanmingmu group. The structure of pancreas was clear basically. Fat cells, infiltrati on of lymphocytes and fibrosis hyperplasia appeared in the interacinar and interlobular connective tissue. Some acinar and islet cells of fatty rat pancreatic tissue had fatty or vesicular degeneration.<p>CONCLUSION: Shuangdanmingmu capsule can decrease blood glucose and glycates hemoglobin in DR rats effectively and improve the ultrastructure of retina and pancreas tissue.http://ies.ijo.cn/cn_publish/2014/11/201411007.pdfdiabetic retinopathyShuangdanmingmu capsuleblood glucoseretinapancreas |
| spellingShingle | Yu-Hui Qin Wen-Juan Li Xi Zhang Zong-Shun Dai Xiao-Liu Chen Ya-Sha Zhou Yan-Jun Ling Bing Zheng Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy Guoji Yanke Zazhi diabetic retinopathy Shuangdanmingmu capsule blood glucose retina pancreas |
| title | Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy |
| title_full | Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy |
| title_fullStr | Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy |
| title_full_unstemmed | Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy |
| title_short | Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy |
| title_sort | effects of shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy |
| topic | diabetic retinopathy Shuangdanmingmu capsule blood glucose retina pancreas |
| url | http://ies.ijo.cn/cn_publish/2014/11/201411007.pdf |
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