Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study
Background and Aim: The global pandemic of COVID-19 has posed an enormous threat to the economy and people's lives across various countries. Patients with COVID-19 most commonly present with respiratory symptoms. However, gastrointestinal (GI) symptoms can also occur. We aimed to study the rela...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.608259/full |
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| author | Rong Chen Rong Chen Yan-li Yu Yan-li Yu Wei Li Ya Liu Jing-xiao Lu Fangyue Chen Qin Zhou Qin Zhou Zhong-yuan Xia Ling Gao Qing-tao Meng Qing-tao Meng Daqing Ma |
| author_facet | Rong Chen Rong Chen Yan-li Yu Yan-li Yu Wei Li Ya Liu Jing-xiao Lu Fangyue Chen Qin Zhou Qin Zhou Zhong-yuan Xia Ling Gao Qing-tao Meng Qing-tao Meng Daqing Ma |
| author_sort | Rong Chen |
| collection | DOAJ |
| description | Background and Aim: The global pandemic of COVID-19 has posed an enormous threat to the economy and people's lives across various countries. Patients with COVID-19 most commonly present with respiratory symptoms. However, gastrointestinal (GI) symptoms can also occur. We aimed to study the relationship between GI symptoms and disease prognosis in patients with COVID-19.Methods: In a single-center and retrospective cohort study, the outcomes in COVID-19 patients with or without GI symptoms were compared. The propensity score is a conditional probability of having a particular exposure (COVID-19 patients with GI symptoms vs. without GI symptoms) given a set of baseline measured covariates. Survival was estimated using the Kaplan-Meier method, and any differences in survival were evaluated with a stratified log-rank-test. To explore the GI symptoms associated with ARDS, non-invasive ventilator treatment, tracheal intubation, tracheotomy, and CRRT, univariable and multivariable COX regression models were used.Results: Among 1,113 eligible patients, 359 patients with GI symptoms and 718 without GI symptoms had similar propensity scores and were included in the analyses. Patients with GI symptoms, as compared with those without GI symptoms, were associated with a similar risk of death, but with higher risks of ARDS, non-invasive mechanical ventilation in COVID-19 patients, respectively.Conclusions: The presence of GI symptoms was associated with a high risk of ARDS, non-invasive mechanical ventilation and tracheal intubation in patients with COVID-19 but not mortality. |
| first_indexed | 2024-12-12T09:15:44Z |
| format | Article |
| id | doaj.art-d8ff2c81c2e34b09885e4d184c4aad30 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T09:15:44Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-d8ff2c81c2e34b09885e4d184c4aad302022-12-22T00:29:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-11-01710.3389/fmed.2020.608259608259Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective StudyRong Chen0Rong Chen1Yan-li Yu2Yan-li Yu3Wei Li4Ya Liu5Jing-xiao Lu6Fangyue Chen7Qin Zhou8Qin Zhou9Zhong-yuan Xia10Ling Gao11Qing-tao Meng12Qing-tao Meng13Daqing Ma14Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Medicine, Peterborough City Hospital, North West Anglia NHS Foundation Trust, Peterborough, United KingdomDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Endocrinology and Metabolism, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, ChinaDivision Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, United KingdomBackground and Aim: The global pandemic of COVID-19 has posed an enormous threat to the economy and people's lives across various countries. Patients with COVID-19 most commonly present with respiratory symptoms. However, gastrointestinal (GI) symptoms can also occur. We aimed to study the relationship between GI symptoms and disease prognosis in patients with COVID-19.Methods: In a single-center and retrospective cohort study, the outcomes in COVID-19 patients with or without GI symptoms were compared. The propensity score is a conditional probability of having a particular exposure (COVID-19 patients with GI symptoms vs. without GI symptoms) given a set of baseline measured covariates. Survival was estimated using the Kaplan-Meier method, and any differences in survival were evaluated with a stratified log-rank-test. To explore the GI symptoms associated with ARDS, non-invasive ventilator treatment, tracheal intubation, tracheotomy, and CRRT, univariable and multivariable COX regression models were used.Results: Among 1,113 eligible patients, 359 patients with GI symptoms and 718 without GI symptoms had similar propensity scores and were included in the analyses. Patients with GI symptoms, as compared with those without GI symptoms, were associated with a similar risk of death, but with higher risks of ARDS, non-invasive mechanical ventilation in COVID-19 patients, respectively.Conclusions: The presence of GI symptoms was associated with a high risk of ARDS, non-invasive mechanical ventilation and tracheal intubation in patients with COVID-19 but not mortality.https://www.frontiersin.org/articles/10.3389/fmed.2020.608259/fullgastrointestinal symptomsCOVID-19prognosisSARS-CoV-2 (COVID-19)ARDS (acute respiratory distress syndrome) |
| spellingShingle | Rong Chen Rong Chen Yan-li Yu Yan-li Yu Wei Li Ya Liu Jing-xiao Lu Fangyue Chen Qin Zhou Qin Zhou Zhong-yuan Xia Ling Gao Qing-tao Meng Qing-tao Meng Daqing Ma Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study Frontiers in Medicine gastrointestinal symptoms COVID-19 prognosis SARS-CoV-2 (COVID-19) ARDS (acute respiratory distress syndrome) |
| title | Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study |
| title_full | Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study |
| title_fullStr | Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study |
| title_full_unstemmed | Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study |
| title_short | Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study |
| title_sort | gastrointestinal symptoms associated with unfavorable prognosis of covid 19 patients a retrospective study |
| topic | gastrointestinal symptoms COVID-19 prognosis SARS-CoV-2 (COVID-19) ARDS (acute respiratory distress syndrome) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.608259/full |
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