The role of Sfrp and DKK proteins in cardiomyocyte development
Abstract In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-02-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.14678 |
| _version_ | 1818650800963977216 |
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| author | Ying‐Chang Hsueh Conrad P. Hodgkinson Jose A. Gomez |
| author_facet | Ying‐Chang Hsueh Conrad P. Hodgkinson Jose A. Gomez |
| author_sort | Ying‐Chang Hsueh |
| collection | DOAJ |
| description | Abstract In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation. |
| first_indexed | 2024-12-17T01:55:59Z |
| format | Article |
| id | doaj.art-d900c84b38f74c2686dc42b6abaa7e22 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-17T01:55:59Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-d900c84b38f74c2686dc42b6abaa7e222022-12-21T22:07:57ZengWileyPhysiological Reports2051-817X2021-02-0193n/an/a10.14814/phy2.14678The role of Sfrp and DKK proteins in cardiomyocyte developmentYing‐Chang Hsueh0Conrad P. Hodgkinson1Jose A. Gomez2Mandel Center for Heart and Vascular Research, and the Duke Cardiovascular Research Center Duke University Medical Center Durham NC USAMandel Center for Heart and Vascular Research, and the Duke Cardiovascular Research Center Duke University Medical Center Durham NC USADepartment of Medicine Clinical Pharmacology Division Vanderbilt University Medical Center Nashville TN USAAbstract In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation.https://doi.org/10.14814/phy2.14678cardiomyocyteDKKSfrp2 |
| spellingShingle | Ying‐Chang Hsueh Conrad P. Hodgkinson Jose A. Gomez The role of Sfrp and DKK proteins in cardiomyocyte development Physiological Reports cardiomyocyte DKK Sfrp2 |
| title | The role of Sfrp and DKK proteins in cardiomyocyte development |
| title_full | The role of Sfrp and DKK proteins in cardiomyocyte development |
| title_fullStr | The role of Sfrp and DKK proteins in cardiomyocyte development |
| title_full_unstemmed | The role of Sfrp and DKK proteins in cardiomyocyte development |
| title_short | The role of Sfrp and DKK proteins in cardiomyocyte development |
| title_sort | role of sfrp and dkk proteins in cardiomyocyte development |
| topic | cardiomyocyte DKK Sfrp2 |
| url | https://doi.org/10.14814/phy2.14678 |
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