The Role of BMP Signaling in Female Reproductive System Development and Function
Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally identified by their ability to induce bone formation, they are now known as essential signaling molecules that regulate the dev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11927 |
| _version_ | 1797512389678071808 |
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| author | Esmeralda Magro-Lopez María Ángeles Muñoz-Fernández |
| author_facet | Esmeralda Magro-Lopez María Ángeles Muñoz-Fernández |
| author_sort | Esmeralda Magro-Lopez |
| collection | DOAJ |
| description | Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally identified by their ability to induce bone formation, they are now known as essential signaling molecules that regulate the development and function of the female reproductive system (FRS). Several BMPs play key roles in aspects of reproductive system development. BMPs have also been described to be involved in the differentiation of human pluripotent stem cells (hPSCs) into reproductive system tissues or organoids. The role of BMPs in the reproductive system is still poorly understood and the use of FRS tissue or organoids generated from hPSCs would provide a powerful tool for the study of FRS development and the generation of new therapeutic perspectives for the treatment of FRS diseases. Therefore, the aim of this review is to summarize the current knowledge about BMP signaling in FRS development and function. |
| first_indexed | 2024-03-10T06:01:08Z |
| format | Article |
| id | doaj.art-d906ce4859dd470fab878c4c753937ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:08Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d906ce4859dd470fab878c4c753937ff2023-11-22T21:00:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122211192710.3390/ijms222111927The Role of BMP Signaling in Female Reproductive System Development and FunctionEsmeralda Magro-Lopez0María Ángeles Muñoz-Fernández1Section Immunology, Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón (HGUGM), 28007 Madrid, SpainSection Immunology, Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón (HGUGM), 28007 Madrid, SpainBone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally identified by their ability to induce bone formation, they are now known as essential signaling molecules that regulate the development and function of the female reproductive system (FRS). Several BMPs play key roles in aspects of reproductive system development. BMPs have also been described to be involved in the differentiation of human pluripotent stem cells (hPSCs) into reproductive system tissues or organoids. The role of BMPs in the reproductive system is still poorly understood and the use of FRS tissue or organoids generated from hPSCs would provide a powerful tool for the study of FRS development and the generation of new therapeutic perspectives for the treatment of FRS diseases. Therefore, the aim of this review is to summarize the current knowledge about BMP signaling in FRS development and function.https://www.mdpi.com/1422-0067/22/21/11927female reproductive systemembryonic developmentBMPs familyBM signalingsignal transductionhuman pluripotent stem cells |
| spellingShingle | Esmeralda Magro-Lopez María Ángeles Muñoz-Fernández The Role of BMP Signaling in Female Reproductive System Development and Function International Journal of Molecular Sciences female reproductive system embryonic development BMPs family BM signaling signal transduction human pluripotent stem cells |
| title | The Role of BMP Signaling in Female Reproductive System Development and Function |
| title_full | The Role of BMP Signaling in Female Reproductive System Development and Function |
| title_fullStr | The Role of BMP Signaling in Female Reproductive System Development and Function |
| title_full_unstemmed | The Role of BMP Signaling in Female Reproductive System Development and Function |
| title_short | The Role of BMP Signaling in Female Reproductive System Development and Function |
| title_sort | role of bmp signaling in female reproductive system development and function |
| topic | female reproductive system embryonic development BMPs family BM signaling signal transduction human pluripotent stem cells |
| url | https://www.mdpi.com/1422-0067/22/21/11927 |
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