In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway
Pharmaceutical agents for halting the progression of Parkinson’s disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/6/315 |
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| author | Chien-Wei Feng Nan-Fu Chen Zhi-Hong Wen Wen-Ya Yang Hsiao-Mei Kuo Ping-Jyun Sung Jui-Hsin Su Shu-Yu Cheng Wu-Fu Chen |
| author_facet | Chien-Wei Feng Nan-Fu Chen Zhi-Hong Wen Wen-Ya Yang Hsiao-Mei Kuo Ping-Jyun Sung Jui-Hsin Su Shu-Yu Cheng Wu-Fu Chen |
| author_sort | Chien-Wei Feng |
| collection | DOAJ |
| description | Pharmaceutical agents for halting the progression of Parkinson’s disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell apoptosis and oxidative stress through PI3K/Akt, MAPK, caspase cascade modulation and Nrf2/HO-1 cascade modulation, respectively. In addition, an in vivo study showed that SB reversed 6-OHDA-induced a locomotor deficit in a zebrafish model of PD. The potential for developing SB as a candidate drug for PD treatment is discussed. |
| first_indexed | 2024-04-14T01:20:06Z |
| format | Article |
| id | doaj.art-d907284a3253431fadb6e9f6861a2117 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:20:06Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-d907284a3253431fadb6e9f6861a21172022-12-22T02:20:40ZengMDPI AGMarine Drugs1660-33972019-05-0117631510.3390/md17060315md17060315In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 PathwayChien-Wei Feng0Nan-Fu Chen1Zhi-Hong Wen2Wen-Ya Yang3Hsiao-Mei Kuo4Ping-Jyun Sung5Jui-Hsin Su6Shu-Yu Cheng7Wu-Fu Chen8National Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanDivision of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanPharmaceutical agents for halting the progression of Parkinson’s disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell apoptosis and oxidative stress through PI3K/Akt, MAPK, caspase cascade modulation and Nrf2/HO-1 cascade modulation, respectively. In addition, an in vivo study showed that SB reversed 6-OHDA-induced a locomotor deficit in a zebrafish model of PD. The potential for developing SB as a candidate drug for PD treatment is discussed.https://www.mdpi.com/1660-3397/17/6/315sponge-derived compoundParkinson’s diseaseoxidative stressapoptosisNrf2HO-1 |
| spellingShingle | Chien-Wei Feng Nan-Fu Chen Zhi-Hong Wen Wen-Ya Yang Hsiao-Mei Kuo Ping-Jyun Sung Jui-Hsin Su Shu-Yu Cheng Wu-Fu Chen In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway Marine Drugs sponge-derived compound Parkinson’s disease oxidative stress apoptosis Nrf2 HO-1 |
| title | In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway |
| title_full | In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway |
| title_fullStr | In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway |
| title_full_unstemmed | In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway |
| title_short | In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway |
| title_sort | in vitro and in vivo neuroprotective effects of stellettin b through anti apoptosis and the nrf2 ho 1 pathway |
| topic | sponge-derived compound Parkinson’s disease oxidative stress apoptosis Nrf2 HO-1 |
| url | https://www.mdpi.com/1660-3397/17/6/315 |
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