Applications of Microarray Technology to Acute Myelogenous Leukemia
Microarray technology is a powerful tool, which has been applied to further the understanding of gene expression changes in disease. Array technology has been applied to the diagnosis and prognosis of Acute Myelogenous Leukemia (AML). Arrays have also been used extensively in elucidating the mechani...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2009-01-01
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| Series: | Cancer Informatics |
| Subjects: | |
| Online Access: | http://www.la-press.com/applications-of-microarray-technology-to-acute-myelogenous-leukemia-a1242 |
| _version_ | 1819004156158935040 |
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| author | Rashmi S. Goswami Mahadeo A. Sukhai Mariam Thomas Patricia P. Reis Suzanne Kamel-Reid |
| author_facet | Rashmi S. Goswami Mahadeo A. Sukhai Mariam Thomas Patricia P. Reis Suzanne Kamel-Reid |
| author_sort | Rashmi S. Goswami |
| collection | DOAJ |
| description | Microarray technology is a powerful tool, which has been applied to further the understanding of gene expression changes in disease. Array technology has been applied to the diagnosis and prognosis of Acute Myelogenous Leukemia (AML). Arrays have also been used extensively in elucidating the mechanism of and predicting therapeutic response in AML, as well as to further define the mechanism of AML pathogenesis. In this review, we discuss the major paradigms of gene expression array analysis, and provide insights into the use of software tools to annotate the array dataset and elucidate deregulated pathways and gene interaction networks. We present the application of gene expression array technology to questions in acute myelogenous leukemia; specifically, disease diagnosis, treatment and prognosis, and disease pathogenesis. Finally, we discuss several new and emerging array technologies, and how they can be further utilized to improve our understanding of AML. |
| first_indexed | 2024-12-20T23:32:25Z |
| format | Article |
| id | doaj.art-d9088b9790b8431088b8af355187c7bb |
| institution | Directory Open Access Journal |
| issn | 1176-9351 |
| language | English |
| last_indexed | 2024-12-20T23:32:25Z |
| publishDate | 2009-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Informatics |
| spelling | doaj.art-d9088b9790b8431088b8af355187c7bb2022-12-21T19:23:16ZengSAGE PublishingCancer Informatics1176-93512009-01-0171328Applications of Microarray Technology to Acute Myelogenous LeukemiaRashmi S. GoswamiMahadeo A. SukhaiMariam ThomasPatricia P. ReisSuzanne Kamel-ReidMicroarray technology is a powerful tool, which has been applied to further the understanding of gene expression changes in disease. Array technology has been applied to the diagnosis and prognosis of Acute Myelogenous Leukemia (AML). Arrays have also been used extensively in elucidating the mechanism of and predicting therapeutic response in AML, as well as to further define the mechanism of AML pathogenesis. In this review, we discuss the major paradigms of gene expression array analysis, and provide insights into the use of software tools to annotate the array dataset and elucidate deregulated pathways and gene interaction networks. We present the application of gene expression array technology to questions in acute myelogenous leukemia; specifically, disease diagnosis, treatment and prognosis, and disease pathogenesis. Finally, we discuss several new and emerging array technologies, and how they can be further utilized to improve our understanding of AML.http://www.la-press.com/applications-of-microarray-technology-to-acute-myelogenous-leukemia-a1242acute myelogenous leukemiagene expression profilingdiagnosticstherapeuticsprognosisdownstream genetic targets |
| spellingShingle | Rashmi S. Goswami Mahadeo A. Sukhai Mariam Thomas Patricia P. Reis Suzanne Kamel-Reid Applications of Microarray Technology to Acute Myelogenous Leukemia Cancer Informatics acute myelogenous leukemia gene expression profiling diagnostics therapeutics prognosis downstream genetic targets |
| title | Applications of Microarray Technology to Acute Myelogenous Leukemia |
| title_full | Applications of Microarray Technology to Acute Myelogenous Leukemia |
| title_fullStr | Applications of Microarray Technology to Acute Myelogenous Leukemia |
| title_full_unstemmed | Applications of Microarray Technology to Acute Myelogenous Leukemia |
| title_short | Applications of Microarray Technology to Acute Myelogenous Leukemia |
| title_sort | applications of microarray technology to acute myelogenous leukemia |
| topic | acute myelogenous leukemia gene expression profiling diagnostics therapeutics prognosis downstream genetic targets |
| url | http://www.la-press.com/applications-of-microarray-technology-to-acute-myelogenous-leukemia-a1242 |
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