Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents

Specific modifications of colchicine followed by synthesis of its analogues have been tested in vitro with the objective of lowering colchicine toxicity. Our previous studies have clearly shown the anticancer potential of double-modified colchicine derivatives in C-7 and C-10 positions. Here, a seri...

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Bibliographic Details
Main Authors:	Urszula Majcher, Greta Klejborowska, Magdalena Kaik, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Jordane Preto, Jack A. Tuszynski, Adam Huczyński
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Series:	Cells
Subjects:	colchicine binding site inhibitor tubulin-targeting agent antimitotic agent antiproliferative activity thiocolchicine natural compounds
Online Access:	https://www.mdpi.com/2073-4409/7/11/216

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