Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation

Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation

The presence of ammonium ions in urine, along with basic pH in the presence of urease-producing bacteria, promotes the production of struvite stones. This causes renal malfunction, which is manifested by symptoms such as fever, nausea, vomiting, and blood in the urine. The involvement of urease in s...

Full description

Bibliographic Details
Main Authors: Kiran Shahzadi, Syed Majid Bukhari, Asma Zaidi, Tanveer A. Wani, Muhammad Saeed Jan, Seema Zargar, Umer Rashid, Umar Farooq, Aneela Khushal, Sara Khan
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
4-aminocoumarin
Schiff bases
urease inhibition
molecular docking
antibacterial activity
MD simulation
Online Access:https://www.mdpi.com/1424-8247/16/11/1552

Similar Items

Similar Items