EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE
OBJECTIVE: To assess biochemical markers after administering Taraxacum officinale’s extract in cisplatin induced nephrotoxic albino mice. METHODS: It was an experimental study, carried out on thirty albino mice categorized into six groups i-e: normal control (saline only), negative control (cispl...
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| Format: | Article |
| Language: | English |
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Khyber Medical University
2019-09-01
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| Series: | Khyber Medical University Journal |
| Subjects: | |
| Online Access: | https://www.kmuj.kmu.edu.pk/article/view/19172 |
| _version_ | 1818065566020141056 |
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| author | Amber Javaid Shafaq Zafar Munazza Khattak Farzana Khan Shumaila Wadud |
| author_facet | Amber Javaid Shafaq Zafar Munazza Khattak Farzana Khan Shumaila Wadud |
| author_sort | Amber Javaid |
| collection | DOAJ |
| description | OBJECTIVE: To assess biochemical markers after administering Taraxacum officinale’s extract in cisplatin induced nephrotoxic albino mice.
METHODS: It was an experimental study, carried out on thirty albino mice categorized into six groups i-e: normal control (saline only), negative control (cisplatin-25mg/kg body weight intraperitoneally) and experimental groups (E1 to E4) (Taraxacum officinale’s extract at doses 100 mg, 200 mg, 400 mg and 800 mg per kg body weight respectively intraperitoneally followed by single dose of cisplatin-25 mg/kg body weight intraperitoneally). Effects of Taraxacum officinale’s extract on kidney were assessed by biochemical markers i-e blood urea and creatinine.
RESULTS: Comparison of blood urea levels in experimental groups (E1, E2, E3 & E4) was much lowered (242±36.6 mg/dl, 176.8±23.9 mg/dl, 179.4±69.5 mg/dl, 186.6±69.05 mg/dl respectively) than the negative control (363±111.1 mg/dl) [p value < 0.05]. Comparison of serum creatinine in negative control versus experimental groups respectively was decreased but statistically insignificant (serum creatinine levels of experimental groups were 1.60±0.65 mg/dl, 1.89±0.32 mg/dl, 1.66±0.62 mg/dl, 1.84±0.55 mg/dl while serum creatinine of negative control was 1.97±1.06 mg/dl) [p value > 0.05].
CONCLUSION: Taraxacum officinale’s extract (dandelion) significantly reduce the effects of renal toxicity produced by the cisplatin but was unable to completely revert cisplatin-induced nephrotoxicity in mice. |
| first_indexed | 2024-12-10T14:53:55Z |
| format | Article |
| id | doaj.art-d90bd0ef9c834560b23c581a59b08254 |
| institution | Directory Open Access Journal |
| issn | 2305-2643 2305-2651 |
| language | English |
| last_indexed | 2024-12-10T14:53:55Z |
| publishDate | 2019-09-01 |
| publisher | Khyber Medical University |
| record_format | Article |
| series | Khyber Medical University Journal |
| spelling | doaj.art-d90bd0ef9c834560b23c581a59b082542022-12-22T01:44:23ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512019-09-0111310.35845/kmuj.2019.19172EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICEAmber Javaid0Shafaq Zafar1Munazza Khattak2Farzana Khan3Shumaila Wadud4Peshawar Medical College, Peshawar, Riphah International University, Islamabad, PakistanPeshawar Medical College, Peshawar, Riphah International University, Islamabad, PakistanPeshawar Medical College, Peshawar, Riphah International University, Islamabad, PakistanPeshawar Medical College, Peshawar, Riphah International University, Islamabad, PakistanPeshawar Medical College, Peshawar, Riphah International University, Islamabad, PakistanOBJECTIVE: To assess biochemical markers after administering Taraxacum officinale’s extract in cisplatin induced nephrotoxic albino mice. METHODS: It was an experimental study, carried out on thirty albino mice categorized into six groups i-e: normal control (saline only), negative control (cisplatin-25mg/kg body weight intraperitoneally) and experimental groups (E1 to E4) (Taraxacum officinale’s extract at doses 100 mg, 200 mg, 400 mg and 800 mg per kg body weight respectively intraperitoneally followed by single dose of cisplatin-25 mg/kg body weight intraperitoneally). Effects of Taraxacum officinale’s extract on kidney were assessed by biochemical markers i-e blood urea and creatinine. RESULTS: Comparison of blood urea levels in experimental groups (E1, E2, E3 & E4) was much lowered (242±36.6 mg/dl, 176.8±23.9 mg/dl, 179.4±69.5 mg/dl, 186.6±69.05 mg/dl respectively) than the negative control (363±111.1 mg/dl) [p value < 0.05]. Comparison of serum creatinine in negative control versus experimental groups respectively was decreased but statistically insignificant (serum creatinine levels of experimental groups were 1.60±0.65 mg/dl, 1.89±0.32 mg/dl, 1.66±0.62 mg/dl, 1.84±0.55 mg/dl while serum creatinine of negative control was 1.97±1.06 mg/dl) [p value > 0.05]. CONCLUSION: Taraxacum officinale’s extract (dandelion) significantly reduce the effects of renal toxicity produced by the cisplatin but was unable to completely revert cisplatin-induced nephrotoxicity in mice.https://www.kmuj.kmu.edu.pk/article/view/19172TaraxacumTaraxacum OfficinaleBiomarkersCisplatinNephrotoxicityHerbal drugs |
| spellingShingle | Amber Javaid Shafaq Zafar Munazza Khattak Farzana Khan Shumaila Wadud EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE Khyber Medical University Journal Taraxacum Taraxacum Officinale Biomarkers Cisplatin Nephrotoxicity Herbal drugs |
| title | EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE |
| title_full | EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE |
| title_fullStr | EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE |
| title_full_unstemmed | EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE |
| title_short | EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE’S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE |
| title_sort | effects of administration of taraxacum officinale s extract on renal parameters in cisplatin induced nephrotoxicity in albino mice |
| topic | Taraxacum Taraxacum Officinale Biomarkers Cisplatin Nephrotoxicity Herbal drugs |
| url | https://www.kmuj.kmu.edu.pk/article/view/19172 |
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