Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study
Background Catheter-related bladder discomfort (CRBD) is a frequent complaint after awakening from anesthesia in patients receiving perioperative bladder catheterization. Overactive bladder (OAB) and CRBD show similar symptoms; thus, drugs used for the management of OAB influence symptoms of CRBD. T...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2020-04-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kja-19198.pdf |
| _version_ | 1828484830546886656 |
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| author | Vinit Kumar Srivastava Sanjay Agrawal Sweta Anil Deshmukh Febin Noushad Saima Khan Raj Kumar |
| author_facet | Vinit Kumar Srivastava Sanjay Agrawal Sweta Anil Deshmukh Febin Noushad Saima Khan Raj Kumar |
| author_sort | Vinit Kumar Srivastava |
| collection | DOAJ |
| description | Background Catheter-related bladder discomfort (CRBD) is a frequent complaint after awakening from anesthesia in patients receiving perioperative bladder catheterization. Overactive bladder (OAB) and CRBD show similar symptoms; thus, drugs used for the management of OAB influence symptoms of CRBD. Trospium chloride has been found effective in managing resistant cases of OAB. We evaluated the efficacy of oral trospium on CRBD in the postoperative period. Methods Sixty-four male and female adult patients, with planned spinal surgery and requiring urinary bladder catheterization, were randomly divided into two groups of 32 each. Group T patients received 60 mg extended-release oral trospium (extended-release) 1 h before induction of anesthesia and Group C patients received a similar-looking placebo. The anesthetic technique was identical in both groups. The CRBD score was evaluated in the postoperative ward using a 4-point scale (1 = no discomfort, 2 = mild, 3 = moderate, 4 = severe). Readings were recorded on arrival (0 h), and 1 h, 2 h, and 6 h postoperatively. All patients received fentanyl for postoperative pain relief. Results The incidence of CRBD was significantly higher in Group C than in Group T at 0 h (66% vs. 22%, P = 0.001) and 1 h postoperatively (72% vs. 28%, P = 0.001). The incidence of moderate to severe CRBD was higher in Group C at postoperative 2 h (82% vs. 14%, P = 0.004). There was no significant difference in postoperative fentanyl requirements. Conclusions Pretreatment with 60 mg extended release trospium reduced the incidence and severity of CRBD in the early postoperative period. |
| first_indexed | 2024-12-11T09:02:27Z |
| format | Article |
| id | doaj.art-d90c67ae14c1486bb9b2125fb922be2b |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-11T09:02:27Z |
| publishDate | 2020-04-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-d90c67ae14c1486bb9b2125fb922be2b2022-12-22T01:13:43ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632020-04-0173214515010.4097/kja.191988582Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind studyVinit Kumar Srivastava0Sanjay Agrawal1Sweta Anil Deshmukh2Febin Noushad3Saima Khan4Raj Kumar5 Department of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India Department of Anesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India Department of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India Department of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India Department of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India Department of Neurosurgery, Apollo Hospitals Bilaspur, Chhattisgarh, IndiaBackground Catheter-related bladder discomfort (CRBD) is a frequent complaint after awakening from anesthesia in patients receiving perioperative bladder catheterization. Overactive bladder (OAB) and CRBD show similar symptoms; thus, drugs used for the management of OAB influence symptoms of CRBD. Trospium chloride has been found effective in managing resistant cases of OAB. We evaluated the efficacy of oral trospium on CRBD in the postoperative period. Methods Sixty-four male and female adult patients, with planned spinal surgery and requiring urinary bladder catheterization, were randomly divided into two groups of 32 each. Group T patients received 60 mg extended-release oral trospium (extended-release) 1 h before induction of anesthesia and Group C patients received a similar-looking placebo. The anesthetic technique was identical in both groups. The CRBD score was evaluated in the postoperative ward using a 4-point scale (1 = no discomfort, 2 = mild, 3 = moderate, 4 = severe). Readings were recorded on arrival (0 h), and 1 h, 2 h, and 6 h postoperatively. All patients received fentanyl for postoperative pain relief. Results The incidence of CRBD was significantly higher in Group C than in Group T at 0 h (66% vs. 22%, P = 0.001) and 1 h postoperatively (72% vs. 28%, P = 0.001). The incidence of moderate to severe CRBD was higher in Group C at postoperative 2 h (82% vs. 14%, P = 0.004). There was no significant difference in postoperative fentanyl requirements. Conclusions Pretreatment with 60 mg extended release trospium reduced the incidence and severity of CRBD in the early postoperative period.http://ekja.org/upload/pdf/kja-19198.pdfantimuscarinicmuscarinic antagonistsmuscarinic receptorsoveractive bladderpostoperative periodtrospium chlorideurinary catheterization |
| spellingShingle | Vinit Kumar Srivastava Sanjay Agrawal Sweta Anil Deshmukh Febin Noushad Saima Khan Raj Kumar Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study Korean Journal of Anesthesiology antimuscarinic muscarinic antagonists muscarinic receptors overactive bladder postoperative period trospium chloride urinary catheterization |
| title | Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study |
| title_full | Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study |
| title_fullStr | Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study |
| title_full_unstemmed | Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study |
| title_short | Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study |
| title_sort | efficacy of trospium for prevention of catheter related bladder discomfort a prospective randomized placebo controlled double blind study |
| topic | antimuscarinic muscarinic antagonists muscarinic receptors overactive bladder postoperative period trospium chloride urinary catheterization |
| url | http://ekja.org/upload/pdf/kja-19198.pdf |
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