Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy
The objective of the present study was to evaluate whether epidural dexmedetomidine (DEX) produces sufficient anti-nociception with reversible sedation and cardiorespiratory changes in sedated dogs undergoing orchiectomy. Twelve male dogs weighing 21.7±5.2 kg were used. Dogs received acepromazine (0...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2019-07-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2617 |
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| author | Hadi IMANI RASTABI Hadi NADDAF Bahman MOSALLANEJAD Ahmad KHAJEH |
| author_facet | Hadi IMANI RASTABI Hadi NADDAF Bahman MOSALLANEJAD Ahmad KHAJEH |
| author_sort | Hadi IMANI RASTABI |
| collection | DOAJ |
| description | The objective of the present study was to evaluate whether epidural dexmedetomidine (DEX) produces sufficient anti-nociception with reversible sedation and cardiorespiratory changes in sedated dogs undergoing orchiectomy. Twelve male dogs weighing 21.7±5.2 kg were used. Dogs received acepromazine (0.025 mg/kg) and morphine (0.25 mg/kg) intramuscularly and a second dose of morphine (0.125 mg/kg) intravenously (IV). DEX (3 μg/kg) was administered epidurally to all dogs (n=12). After confirming complete sensory blockade of the prescrotal region, orchiectomy was performed. If any discomfort was detected during surgery, 2-3 mL lidocaine 1% (maximum two times) was applied into the painful area. Sixty minutes after epidural application, dogs were randomly assigned to receive either treatment of atipamezole (ATP; n=6) or saline (SAL; n=6) IV. None of the dogs required general anesthesia; however, nine out of twelve dogs received lidocaine. The duration of sensory blockade was significantly shorter in ATP than that of SAL. Heart rate, respiratory rate, and rectal temperature showed significantly lower values compared with base after administration of DEX. Administration of atipamezole reversed sedation, sensory blockade and cardiorespiratory changes. In conclusion, epidural DEX did not produce adequate anti-nociception during orchiectomy in sedated dogs. Sedation, sensory blockade and cardiorespiratory changes induced by epidural DEX can be reversed by IV administration of atipamezole. |
| first_indexed | 2024-03-13T04:38:45Z |
| format | Article |
| id | doaj.art-d90c943fc75045968e7fd0ae9c179987 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:38:45Z |
| publishDate | 2019-07-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-d90c943fc75045968e7fd0ae9c1799872023-06-19T06:34:00ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512019-07-0125680781310.9775/kvfd.2019.219432617Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomyHadi IMANI RASTABI0Hadi NADDAF1Bahman MOSALLANEJAD2Ahmad KHAJEH3Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IRANDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IRANDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IRANDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IRANThe objective of the present study was to evaluate whether epidural dexmedetomidine (DEX) produces sufficient anti-nociception with reversible sedation and cardiorespiratory changes in sedated dogs undergoing orchiectomy. Twelve male dogs weighing 21.7±5.2 kg were used. Dogs received acepromazine (0.025 mg/kg) and morphine (0.25 mg/kg) intramuscularly and a second dose of morphine (0.125 mg/kg) intravenously (IV). DEX (3 μg/kg) was administered epidurally to all dogs (n=12). After confirming complete sensory blockade of the prescrotal region, orchiectomy was performed. If any discomfort was detected during surgery, 2-3 mL lidocaine 1% (maximum two times) was applied into the painful area. Sixty minutes after epidural application, dogs were randomly assigned to receive either treatment of atipamezole (ATP; n=6) or saline (SAL; n=6) IV. None of the dogs required general anesthesia; however, nine out of twelve dogs received lidocaine. The duration of sensory blockade was significantly shorter in ATP than that of SAL. Heart rate, respiratory rate, and rectal temperature showed significantly lower values compared with base after administration of DEX. Administration of atipamezole reversed sedation, sensory blockade and cardiorespiratory changes. In conclusion, epidural DEX did not produce adequate anti-nociception during orchiectomy in sedated dogs. Sedation, sensory blockade and cardiorespiratory changes induced by epidural DEX can be reversed by IV administration of atipamezole.https://vetdergikafkas.org/pdf.php?id=2617atipamezoledexmedetomidineepidural anesthesiaorchiectomy |
| spellingShingle | Hadi IMANI RASTABI Hadi NADDAF Bahman MOSALLANEJAD Ahmad KHAJEH Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy Kafkas Universitesi Veteriner Fakültesi Dergisi atipamezole dexmedetomidine epidural anesthesia orchiectomy |
| title | Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy |
| title_full | Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy |
| title_fullStr | Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy |
| title_full_unstemmed | Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy |
| title_short | Evaluation of the feasibility, reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy |
| title_sort | evaluation of the feasibility reversibility and cardiorespiratory effects of epidural dexmedetomidine in sedated dogs undergoing orchiectomy |
| topic | atipamezole dexmedetomidine epidural anesthesia orchiectomy |
| url | https://vetdergikafkas.org/pdf.php?id=2617 |
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