Fatal Nevirapine-Induced Toxic Epidermal Necrolysis in a HIV Infected Patient
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are the most Severe Cutaneous Adverse Reactions (SCARs) which mainly caused by exposure to drugs and having significant morbidity and mortality. TEN represents an immunologic reaction to a foreign antigen and is most often caused...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7415/16360_CE(RA1)_F(T)_PF1(VIAK)_PFA(AK)_PF2(PRO).pdf |
| Summary: | Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are the most Severe Cutaneous Adverse Reactions (SCARs)
which mainly caused by exposure to drugs and having significant morbidity and mortality. TEN represents an immunologic reaction to
a foreign antigen and is most often caused by drugs. Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor (NNRTI) is an
important component of Highly Active Antiretroviral Therapy (HAART). It is sometimes associated with life-threatening adverse reactions.
Here, we report the fatal case of 72-year-old male who developed TEN secondary to intake of nevirapine. This fatal case report will
increase awareness among treating physicians for careful monitoring of patients on NNRTI-based antiretroviral therapy and better
counseling of the patient on NVP regimen for early identification and reporting of SCARs so that fatalities due to adverse drug reactions
can be prevented with timely intervention. |
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| ISSN: | 2249-782X 0973-709X |