Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels.
PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the car...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3532160?pdf=render |
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| author | Elisa Barbati Claudia Specchia Massimo Villella Marco Luciano Rossi Simona Barlera Barbara Bottazzi Luisa Crociati Carmela d'Arienzo Raffaele Fanelli Cecilia Garlanda Francesca Gori Ruggiero Mango Alberto Mantovani Giuseppe Merla Enrico B Nicolis Silvia Pietri Patrizia Presbitero Yukio Sudo Alessandro Villella Maria Grazia Franzosi |
| author_facet | Elisa Barbati Claudia Specchia Massimo Villella Marco Luciano Rossi Simona Barlera Barbara Bottazzi Luisa Crociati Carmela d'Arienzo Raffaele Fanelli Cecilia Garlanda Francesca Gori Ruggiero Mango Alberto Mantovani Giuseppe Merla Enrico B Nicolis Silvia Pietri Patrizia Presbitero Yukio Sudo Alessandro Villella Maria Grazia Franzosi |
| author_sort | Elisa Barbati |
| collection | DOAJ |
| description | PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the cardiovascular system. PTX3 plasma concentration is an independent predictor of mortality in patients with acute myocardial infarction (AMI) but the influence of PTX3 genetic variants on PTX3 plasma concentration has been investigated very little and there is no information on the association between PTX3 variations and AMI. Subjects of European origin (3245, 1751 AMI survivors and 1494 controls) were genotyped for three common PTX3 polymorphisms (SNPs) (rs2305619, rs3816527, rs1840680). Genotype and allele frequencies of the three SNPs and the haplotype frequencies were compared for the two groups. None of the genotypes, alleles or haplotypes were significantly associated with the risk of AMI. However, analysis adjusted for age and sex indicated that the three PTX3 SNPs and the corresponding haplotypes were significantly associated with different PTX3 plasma levels. There was also a significant association between PTX3 plasma concentrations and the risk of all-cause mortality at three years in AMI patients (OR 1.10, 95% CI: 1.01-1.20, p = 0.02). Our study showed that PTX3 plasma levels are influenced by three PTX3 polymorphisms. Genetically determined high PTX3 levels do not influence the risk of AMI, suggesting that the PTX3 concentration itself is unlikely to be even a modest causal factor for AMI. Analysis also confirmed that PTX3 is a prognostic marker after AMI. |
| first_indexed | 2024-12-21T14:03:35Z |
| format | Article |
| id | doaj.art-d90cee926a394e0fa636452847d7ef13 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T14:03:35Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-d90cee926a394e0fa636452847d7ef132022-12-21T19:01:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5303010.1371/journal.pone.0053030Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels.Elisa BarbatiClaudia SpecchiaMassimo VillellaMarco Luciano RossiSimona BarleraBarbara BottazziLuisa CrociatiCarmela d'ArienzoRaffaele FanelliCecilia GarlandaFrancesca GoriRuggiero MangoAlberto MantovaniGiuseppe MerlaEnrico B NicolisSilvia PietriPatrizia PresbiteroYukio SudoAlessandro VillellaMaria Grazia FranzosiPTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the cardiovascular system. PTX3 plasma concentration is an independent predictor of mortality in patients with acute myocardial infarction (AMI) but the influence of PTX3 genetic variants on PTX3 plasma concentration has been investigated very little and there is no information on the association between PTX3 variations and AMI. Subjects of European origin (3245, 1751 AMI survivors and 1494 controls) were genotyped for three common PTX3 polymorphisms (SNPs) (rs2305619, rs3816527, rs1840680). Genotype and allele frequencies of the three SNPs and the haplotype frequencies were compared for the two groups. None of the genotypes, alleles or haplotypes were significantly associated with the risk of AMI. However, analysis adjusted for age and sex indicated that the three PTX3 SNPs and the corresponding haplotypes were significantly associated with different PTX3 plasma levels. There was also a significant association between PTX3 plasma concentrations and the risk of all-cause mortality at three years in AMI patients (OR 1.10, 95% CI: 1.01-1.20, p = 0.02). Our study showed that PTX3 plasma levels are influenced by three PTX3 polymorphisms. Genetically determined high PTX3 levels do not influence the risk of AMI, suggesting that the PTX3 concentration itself is unlikely to be even a modest causal factor for AMI. Analysis also confirmed that PTX3 is a prognostic marker after AMI.http://europepmc.org/articles/PMC3532160?pdf=render |
| spellingShingle | Elisa Barbati Claudia Specchia Massimo Villella Marco Luciano Rossi Simona Barlera Barbara Bottazzi Luisa Crociati Carmela d'Arienzo Raffaele Fanelli Cecilia Garlanda Francesca Gori Ruggiero Mango Alberto Mantovani Giuseppe Merla Enrico B Nicolis Silvia Pietri Patrizia Presbitero Yukio Sudo Alessandro Villella Maria Grazia Franzosi Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. PLoS ONE |
| title | Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. |
| title_full | Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. |
| title_fullStr | Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. |
| title_full_unstemmed | Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. |
| title_short | Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. |
| title_sort | influence of pentraxin 3 ptx3 genetic variants on myocardial infarction risk and ptx3 plasma levels |
| url | http://europepmc.org/articles/PMC3532160?pdf=render |
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