Hematologic complications in vascular malformations: A case study of 2 patients
Vascular malformations are congenital vascular anomalies resulting from a disruption in the vasculogenesis process. (1) They are congenital changes that enlarge as the child develops and do not undergo spontaneous involution. They can be classified based on the type of vessels involved (capillary,...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2024-02-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/48319 |
| _version_ | 1797303547753136128 |
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| author | Iwona Matus Kaja Bator Weronika Machaj Aleksandra Krzemienowska-Cebulla Mateusz Dorochowicz Hanna Senat Adrian Korbecki Andrzej Szuba Maciej Rabczyński |
| author_facet | Iwona Matus Kaja Bator Weronika Machaj Aleksandra Krzemienowska-Cebulla Mateusz Dorochowicz Hanna Senat Adrian Korbecki Andrzej Szuba Maciej Rabczyński |
| author_sort | Iwona Matus |
| collection | DOAJ |
| description | Vascular malformations are congenital vascular anomalies resulting from a disruption in the vasculogenesis process. (1) They are congenital changes that enlarge as the child develops and do not undergo spontaneous involution. They can be classified based on the type of vessels involved (capillary, arterial, venous, lymphatic, mixed) and the nature of the vascular flow (low-flow and high-flow). The clinical presentation of vascular malformations is highly diverse, and despite being congenital, they can remain asymptomatic for a long time, complicating the diagnostic process. (1,3)
The presence of malformations carries the risk of health-threatening complications. One such complication is Kasabach-Merritt syndrome, characterized by thrombocytopenia, microangiopathic hemolytic anemia, and consumptive coagulopathy in the presence of a rapidly enlarging vascular tumor. (4,5) Another threat is a coagulopathy limited to the vascular anomaly (LIC). It is characterized by elevated D-dimers and fibrin degradation products, low levels of fibrinogen, FV, FVIII, FXIII, and antithrombin, and sometimes mild to moderate thrombocytopenia. (6,7) Early implementation of anticoagulant therapy allows for the avoidance of health-threatening conditions and the development of disseminated intravascular coagulation syndrome (DIC). (8)
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| first_indexed | 2024-03-07T23:55:20Z |
| format | Article |
| id | doaj.art-d90df1ce236742ba8dc1849f8e31f6dc |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-03-07T23:55:20Z |
| publishDate | 2024-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-d90df1ce236742ba8dc1849f8e31f6dc2024-02-18T11:52:54ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062024-02-016110.12775/JEHS.2024.61.002Hematologic complications in vascular malformations: A case study of 2 patientsIwona Matus0Kaja Bator1Weronika Machaj2Aleksandra Krzemienowska-Cebulla3Mateusz Dorochowicz4Hanna Senat5Adrian Korbecki6Andrzej Szuba7Maciej Rabczyński8Faculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wroclaw, PolandDivision of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wroclaw, PolandDivision of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Borowska 213, 50-556 WroclawClinical Department of Angiology and Internal Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandClinical Department of Diabetology and Internal Diseases, Medical University, Borowska 213, 50-556 Wroclaw, PolandVascular malformations are congenital vascular anomalies resulting from a disruption in the vasculogenesis process. (1) They are congenital changes that enlarge as the child develops and do not undergo spontaneous involution. They can be classified based on the type of vessels involved (capillary, arterial, venous, lymphatic, mixed) and the nature of the vascular flow (low-flow and high-flow). The clinical presentation of vascular malformations is highly diverse, and despite being congenital, they can remain asymptomatic for a long time, complicating the diagnostic process. (1,3) The presence of malformations carries the risk of health-threatening complications. One such complication is Kasabach-Merritt syndrome, characterized by thrombocytopenia, microangiopathic hemolytic anemia, and consumptive coagulopathy in the presence of a rapidly enlarging vascular tumor. (4,5) Another threat is a coagulopathy limited to the vascular anomaly (LIC). It is characterized by elevated D-dimers and fibrin degradation products, low levels of fibrinogen, FV, FVIII, FXIII, and antithrombin, and sometimes mild to moderate thrombocytopenia. (6,7) Early implementation of anticoagulant therapy allows for the avoidance of health-threatening conditions and the development of disseminated intravascular coagulation syndrome (DIC). (8) https://apcz.umk.pl/JEHS/article/view/48319vascular malformationLICDICKasabach-Merritt syndrome |
| spellingShingle | Iwona Matus Kaja Bator Weronika Machaj Aleksandra Krzemienowska-Cebulla Mateusz Dorochowicz Hanna Senat Adrian Korbecki Andrzej Szuba Maciej Rabczyński Hematologic complications in vascular malformations: A case study of 2 patients Journal of Education, Health and Sport vascular malformation LIC DIC Kasabach-Merritt syndrome |
| title | Hematologic complications in vascular malformations: A case study of 2 patients |
| title_full | Hematologic complications in vascular malformations: A case study of 2 patients |
| title_fullStr | Hematologic complications in vascular malformations: A case study of 2 patients |
| title_full_unstemmed | Hematologic complications in vascular malformations: A case study of 2 patients |
| title_short | Hematologic complications in vascular malformations: A case study of 2 patients |
| title_sort | hematologic complications in vascular malformations a case study of 2 patients |
| topic | vascular malformation LIC DIC Kasabach-Merritt syndrome |
| url | https://apcz.umk.pl/JEHS/article/view/48319 |
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