The correlation between serum total alkaline phosphatase and bone mineral density in young adults
Abstract Background Elevated total alkaline phosphatase (T-ALP) levels are usually indicative of enhanced osteoblastic activity and bone conversion status and are thus considered as a key factor needed for fresh bone mineralization and synthesis. To date, there is no consistent conclusion on the ass...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-022-05438-y |
| _version_ | 1818548893437132800 |
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| author | Juntao Shu Anjun Tan Yan Li Hong Huang Jingjing Yang |
| author_facet | Juntao Shu Anjun Tan Yan Li Hong Huang Jingjing Yang |
| author_sort | Juntao Shu |
| collection | DOAJ |
| description | Abstract Background Elevated total alkaline phosphatase (T-ALP) levels are usually indicative of enhanced osteoblastic activity and bone conversion status and are thus considered as a key factor needed for fresh bone mineralization and synthesis. To date, there is no consistent conclusion on the association between the serum T-ALP levels and bone mineral density (BMD). Therefore, the present study focused on exploring the association of serum T-ALP with lumbar BMD among young adults. Methods The present cross-sectional study included 6,331 subjects included in the National Health and Nutrition Examination Survey (NHANES) during 2011–2016. The participants aged 20–40 years included 3,349 males and 2,982 females. Serum T-ALP was our main variable, lumbar BMD was our outcome variable, and additional variables were the possible impact modifiers. The relations were analysed by the trend study, weighted multiple linear regression models, smooth curve fitting, and stratified analyses. Results In a completely corrected multiple regression model, a negative association between serum T-ALP and lumbar BMD was discovered (β = -0.0007, 95% CI: –0.0009– –0.0005, P < 0.000001). After converting the continuous variable serum T-ALP into the categorical one, the significant negative association was still observed (P < 0.001), and in the subgroup and smooth curve fitting analyses, this negative correlation remained significant, too. Conclusions Our study results indicated that serum T-ALP was negatively associated with lumbar BMD among young adults. Serum T-ALP measurement in the near future might become an effective biomarker to diagnose and treat osteoporosis on time. |
| first_indexed | 2024-12-12T08:26:20Z |
| format | Article |
| id | doaj.art-d90e051fc94c427e8512f9e0577a4a81 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-12T08:26:20Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-d90e051fc94c427e8512f9e0577a4a812022-12-22T00:31:14ZengBMCBMC Musculoskeletal Disorders1471-24742022-05-012311810.1186/s12891-022-05438-yThe correlation between serum total alkaline phosphatase and bone mineral density in young adultsJuntao Shu0Anjun Tan1Yan Li2Hong Huang3Jingjing Yang4Department of Neonatology, The Children’s Hospital of Kunming City, The Affiliated Children’s Hospital of Kunming Medical UniversityDepartment of Geriatrics, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and TechnologyDepartment of Geriatrics, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and TechnologyDepartment of Geriatrics, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and TechnologyDepartment of Geriatrics, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and TechnologyAbstract Background Elevated total alkaline phosphatase (T-ALP) levels are usually indicative of enhanced osteoblastic activity and bone conversion status and are thus considered as a key factor needed for fresh bone mineralization and synthesis. To date, there is no consistent conclusion on the association between the serum T-ALP levels and bone mineral density (BMD). Therefore, the present study focused on exploring the association of serum T-ALP with lumbar BMD among young adults. Methods The present cross-sectional study included 6,331 subjects included in the National Health and Nutrition Examination Survey (NHANES) during 2011–2016. The participants aged 20–40 years included 3,349 males and 2,982 females. Serum T-ALP was our main variable, lumbar BMD was our outcome variable, and additional variables were the possible impact modifiers. The relations were analysed by the trend study, weighted multiple linear regression models, smooth curve fitting, and stratified analyses. Results In a completely corrected multiple regression model, a negative association between serum T-ALP and lumbar BMD was discovered (β = -0.0007, 95% CI: –0.0009– –0.0005, P < 0.000001). After converting the continuous variable serum T-ALP into the categorical one, the significant negative association was still observed (P < 0.001), and in the subgroup and smooth curve fitting analyses, this negative correlation remained significant, too. Conclusions Our study results indicated that serum T-ALP was negatively associated with lumbar BMD among young adults. Serum T-ALP measurement in the near future might become an effective biomarker to diagnose and treat osteoporosis on time.https://doi.org/10.1186/s12891-022-05438-ySerum total alkaline phosphataseBone mineral densityNHANESCross-sectional study |
| spellingShingle | Juntao Shu Anjun Tan Yan Li Hong Huang Jingjing Yang The correlation between serum total alkaline phosphatase and bone mineral density in young adults BMC Musculoskeletal Disorders Serum total alkaline phosphatase Bone mineral density NHANES Cross-sectional study |
| title | The correlation between serum total alkaline phosphatase and bone mineral density in young adults |
| title_full | The correlation between serum total alkaline phosphatase and bone mineral density in young adults |
| title_fullStr | The correlation between serum total alkaline phosphatase and bone mineral density in young adults |
| title_full_unstemmed | The correlation between serum total alkaline phosphatase and bone mineral density in young adults |
| title_short | The correlation between serum total alkaline phosphatase and bone mineral density in young adults |
| title_sort | correlation between serum total alkaline phosphatase and bone mineral density in young adults |
| topic | Serum total alkaline phosphatase Bone mineral density NHANES Cross-sectional study |
| url | https://doi.org/10.1186/s12891-022-05438-y |
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