Dysregulation of Wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy

Dysregulation of Wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy

Abstract Background Type 2 diabetes mellitus (T2DM) patients show a markedly higher fracture risk and impaired fracture healing when compared to non-diabetic patients. However in contrast to type 1 diabetes mellitus, bone mineral density in T2DM is known to be normal or even regionally elevated, als...

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Main Authors: Laurens Christian Gassel, Sandra Schneider, Ingo Jörg Banke, Karl Friedrich Braun, Christoph Volkering, Leonie Zeeb, Rainer Hans Hermann Burgkart, Rüdiger von Eisenhart-Rothe, Peter Biberthaler, Martijn van Griensven, Alexander Tobias Haug
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
Diabetic bone disease
Type 2 diabetes mellitus
Wnt signaling
TCF7L2
Osteocalcin
Online Access:https://doi.org/10.1186/s12891-022-05314-9

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