Inflammasomes and their roles in arthritic disease pathogenesis
The inflammasome is a molecular platform that is created in the cytosolic compartment to mediate the host immunological response to cellular injury and infection. Caspase-1 may be activated by the inflammasome, which leads to the generation of the inflammatory cytokines interleukin-1β (IL-1β) and IL...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1027917/full |
| _version_ | 1797989793810874368 |
|---|---|
| author | Gabsik Yang Han Chang Kang Yong-Yeon Cho Hye Suk Lee Joo Young Lee |
| author_facet | Gabsik Yang Han Chang Kang Yong-Yeon Cho Hye Suk Lee Joo Young Lee |
| author_sort | Gabsik Yang |
| collection | DOAJ |
| description | The inflammasome is a molecular platform that is created in the cytosolic compartment to mediate the host immunological response to cellular injury and infection. Caspase-1 may be activated by the inflammasome, which leads to the generation of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18 and the beginning of pyroptosis, which is a type of proinflammatory cell death. Scientists have identified a number of different inflammasomes in the last 2 decades. The NLRP3 inflammasome has been studied the most, and its activity may be triggered by a broad range of different inducers. However, activation of the NLRP3 inflammasome in a manner that is not properly controlled is also a factor in the etiology of many human illnesses. Accumulating evidence indicates that the NLRP3 inflammasome plays a significant role in the innate and adaptive immune systems and the development of various arthritic illnesses, such as rheumatoid arthritis, ankylosing spondylitis, and gout. The present review provides a concise summary of the biological properties of the NLRP3 inflammasome and presents the fundamental processes behind its activation and control. We discuss the role of the inflammasome in the pathogenesis of arthritic diseases, such as rheumatoid arthritis, ankylosing spondylitis, and gout, and the potential of newly developed therapies that specifically target the inflammasome or its products for the treatment of inflammatory diseases, with a particular emphasis on treatment and clinical application. |
| first_indexed | 2024-04-11T08:25:07Z |
| format | Article |
| id | doaj.art-d910f13fa455472592a7151893733950 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-11T08:25:07Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-d910f13fa455472592a71518937339502022-12-22T04:34:47ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-10-01910.3389/fmolb.2022.10279171027917Inflammasomes and their roles in arthritic disease pathogenesisGabsik Yang0Han Chang Kang1Yong-Yeon Cho2Hye Suk Lee3Joo Young Lee4Department of Pharmacology, College of Korean Medicine, Woosuk University, Jeonju, South KoreaCollege of Pharmacy, The Catholic University of Korea, Seoul, South KoreaCollege of Pharmacy, The Catholic University of Korea, Seoul, South KoreaCollege of Pharmacy, The Catholic University of Korea, Seoul, South KoreaCollege of Pharmacy, The Catholic University of Korea, Seoul, South KoreaThe inflammasome is a molecular platform that is created in the cytosolic compartment to mediate the host immunological response to cellular injury and infection. Caspase-1 may be activated by the inflammasome, which leads to the generation of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18 and the beginning of pyroptosis, which is a type of proinflammatory cell death. Scientists have identified a number of different inflammasomes in the last 2 decades. The NLRP3 inflammasome has been studied the most, and its activity may be triggered by a broad range of different inducers. However, activation of the NLRP3 inflammasome in a manner that is not properly controlled is also a factor in the etiology of many human illnesses. Accumulating evidence indicates that the NLRP3 inflammasome plays a significant role in the innate and adaptive immune systems and the development of various arthritic illnesses, such as rheumatoid arthritis, ankylosing spondylitis, and gout. The present review provides a concise summary of the biological properties of the NLRP3 inflammasome and presents the fundamental processes behind its activation and control. We discuss the role of the inflammasome in the pathogenesis of arthritic diseases, such as rheumatoid arthritis, ankylosing spondylitis, and gout, and the potential of newly developed therapies that specifically target the inflammasome or its products for the treatment of inflammatory diseases, with a particular emphasis on treatment and clinical application.https://www.frontiersin.org/articles/10.3389/fmolb.2022.1027917/fullinflammationpharmacological inhibitorstherapeutic targetsimmunitypattern recognition receptors |
| spellingShingle | Gabsik Yang Han Chang Kang Yong-Yeon Cho Hye Suk Lee Joo Young Lee Inflammasomes and their roles in arthritic disease pathogenesis Frontiers in Molecular Biosciences inflammation pharmacological inhibitors therapeutic targets immunity pattern recognition receptors |
| title | Inflammasomes and their roles in arthritic disease pathogenesis |
| title_full | Inflammasomes and their roles in arthritic disease pathogenesis |
| title_fullStr | Inflammasomes and their roles in arthritic disease pathogenesis |
| title_full_unstemmed | Inflammasomes and their roles in arthritic disease pathogenesis |
| title_short | Inflammasomes and their roles in arthritic disease pathogenesis |
| title_sort | inflammasomes and their roles in arthritic disease pathogenesis |
| topic | inflammation pharmacological inhibitors therapeutic targets immunity pattern recognition receptors |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1027917/full |
| work_keys_str_mv | AT gabsikyang inflammasomesandtheirrolesinarthriticdiseasepathogenesis AT hanchangkang inflammasomesandtheirrolesinarthriticdiseasepathogenesis AT yongyeoncho inflammasomesandtheirrolesinarthriticdiseasepathogenesis AT hyesuklee inflammasomesandtheirrolesinarthriticdiseasepathogenesis AT jooyounglee inflammasomesandtheirrolesinarthriticdiseasepathogenesis |