COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report
Abstract SARS‐CoV‐2 infection can manifest many rashes. However, thrombotic retiform purpura rarely occurs during COVID‐19 illness. Aggressive anti‐COVID‐19 therapy with a high‐dose steroid regimen led to rapid recovery. This immunothrombotic phenomenon likely represents a poor type 1 interferon res...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.6790 |
| _version_ | 1797951476995194880 |
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| author | Connor M. Bunch Nuha Zackariya Anthony V. Thomas Jack H. Langford Michael Aboukhaled Samuel J. Thomas Aida Ansari Shivani S. Patel Hallie Buckner Joseph B. Miller Christy L. Annis Margaret A. Quate‐Operacz Leslie A. Schmitz Joseph J. Pulvirenti Jonathan C. Konopinski Kathleen M. Kelley Samer Hassna Luke G. Nelligan Mark M. Walsh |
| author_facet | Connor M. Bunch Nuha Zackariya Anthony V. Thomas Jack H. Langford Michael Aboukhaled Samuel J. Thomas Aida Ansari Shivani S. Patel Hallie Buckner Joseph B. Miller Christy L. Annis Margaret A. Quate‐Operacz Leslie A. Schmitz Joseph J. Pulvirenti Jonathan C. Konopinski Kathleen M. Kelley Samer Hassna Luke G. Nelligan Mark M. Walsh |
| author_sort | Connor M. Bunch |
| collection | DOAJ |
| description | Abstract SARS‐CoV‐2 infection can manifest many rashes. However, thrombotic retiform purpura rarely occurs during COVID‐19 illness. Aggressive anti‐COVID‐19 therapy with a high‐dose steroid regimen led to rapid recovery. This immunothrombotic phenomenon likely represents a poor type 1 interferon response and complement activation on the endothelial surface in response to acute infection. |
| first_indexed | 2024-04-10T22:31:11Z |
| format | Article |
| id | doaj.art-d911538805bb4417ace482c0492da8e4 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-04-10T22:31:11Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-d911538805bb4417ace482c0492da8e42023-01-17T04:40:57ZengWileyClinical Case Reports2050-09042022-12-011012n/an/a10.1002/ccr3.6790COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case reportConnor M. Bunch0Nuha Zackariya1Anthony V. Thomas2Jack H. Langford3Michael Aboukhaled4Samuel J. Thomas5Aida Ansari6Shivani S. Patel7Hallie Buckner8Joseph B. Miller9Christy L. Annis10Margaret A. Quate‐Operacz11Leslie A. Schmitz12Joseph J. Pulvirenti13Jonathan C. Konopinski14Kathleen M. Kelley15Samer Hassna16Luke G. Nelligan17Mark M. Walsh18Departments of Emergency Medicine and Internal Medicine Henry Ford Hospital Detroit Michigan USAIndiana University School of Medicine—South Bend South Bend Indiana USAIndiana University School of Medicine—South Bend South Bend Indiana USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USADepartments of Emergency Medicine and Internal Medicine Henry Ford Hospital Detroit Michigan USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USAKidney Care of Michiana Mishawaka Indiana USAKidney Care of Michiana Mishawaka Indiana USADepartment of Infectious Disease Saint Joseph Regional Medical Center Mishawaka Indiana USADepartment of Pathology South Bend Medical Foundation South Bend Indiana USADepartment of Dermatology Beacon Medical Group Granger Indiana USADepartment of Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USADepartment of Family Medicine Marian University College of Osteopathic Medicine Indianapolis Indiana USADepartments of Emergency Medicine and Internal Medicine Saint Joseph Regional Medical Center Mishawaka Indiana USAAbstract SARS‐CoV‐2 infection can manifest many rashes. However, thrombotic retiform purpura rarely occurs during COVID‐19 illness. Aggressive anti‐COVID‐19 therapy with a high‐dose steroid regimen led to rapid recovery. This immunothrombotic phenomenon likely represents a poor type 1 interferon response and complement activation on the endothelial surface in response to acute infection.https://doi.org/10.1002/ccr3.6790acral lesionschilblainsCOVID‐19exanthemapurpuraSARS‐CoV‐2 |
| spellingShingle | Connor M. Bunch Nuha Zackariya Anthony V. Thomas Jack H. Langford Michael Aboukhaled Samuel J. Thomas Aida Ansari Shivani S. Patel Hallie Buckner Joseph B. Miller Christy L. Annis Margaret A. Quate‐Operacz Leslie A. Schmitz Joseph J. Pulvirenti Jonathan C. Konopinski Kathleen M. Kelley Samer Hassna Luke G. Nelligan Mark M. Walsh COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report Clinical Case Reports acral lesions chilblains COVID‐19 exanthema purpura SARS‐CoV‐2 |
| title | COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report |
| title_full | COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report |
| title_fullStr | COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report |
| title_full_unstemmed | COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report |
| title_short | COVID‐associated non‐vasculitic thrombotic retiform purpura of the face and extremities: A case report |
| title_sort | covid associated non vasculitic thrombotic retiform purpura of the face and extremities a case report |
| topic | acral lesions chilblains COVID‐19 exanthema purpura SARS‐CoV‐2 |
| url | https://doi.org/10.1002/ccr3.6790 |
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