The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway
Objective: To determine the effect of Shu Xue Tong treatment on random skin flap survival. Methods: Twenty-four male Sprague–Dawley (SD) rats were administered Shu Xue Tong or normal saline. On postoperative day 7, flap survival area, flap angiogenesis angiography, blood flow and vascular endothelia...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-08-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2018.1551948 |
| _version_ | 1797684704109920256 |
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| author | Chaoyang Qi Yuting Lin Dingsheng Lin |
| author_facet | Chaoyang Qi Yuting Lin Dingsheng Lin |
| author_sort | Chaoyang Qi |
| collection | DOAJ |
| description | Objective: To determine the effect of Shu Xue Tong treatment on random skin flap survival. Methods: Twenty-four male Sprague–Dawley (SD) rats were administered Shu Xue Tong or normal saline. On postoperative day 7, flap survival area, flap angiogenesis angiography, blood flow and vascular endothelial growth factor (VEGF), Notch1, and Delta-like ligand 4 (Dll4) expression were assessed. Results: The mean flap survival area, blood vessel regeneration, microcirculatory flow, and expression of VEGF were enhanced with Shu Xue Tong treatment relative to the control. However, in Shu Xue Tong-treated rat flap, Notch1 and Dll4 levels were significantly reduced. Conclusions: These results demonstrate the beneficial action of Shu Xue Tong on random skin flap survival and suggest that its mechanism of action involves the promotion of angiogenesis via the VEGF-Notch1/Dll4 signaling pathway. |
| first_indexed | 2024-03-12T00:33:35Z |
| format | Article |
| id | doaj.art-d91154578b15413ea92f4c0f56184657 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:33:35Z |
| publishDate | 2020-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-d91154578b15413ea92f4c0f561846572023-09-15T10:07:29ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532020-08-0133761562010.1080/08941939.2018.15519481551948The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling PathwayChaoyang Qi0Yuting Lin1Dingsheng Lin2The Second Affiliated Hospital Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital Yuying Children’s Hospital of Wenzhou Medical UniversityObjective: To determine the effect of Shu Xue Tong treatment on random skin flap survival. Methods: Twenty-four male Sprague–Dawley (SD) rats were administered Shu Xue Tong or normal saline. On postoperative day 7, flap survival area, flap angiogenesis angiography, blood flow and vascular endothelial growth factor (VEGF), Notch1, and Delta-like ligand 4 (Dll4) expression were assessed. Results: The mean flap survival area, blood vessel regeneration, microcirculatory flow, and expression of VEGF were enhanced with Shu Xue Tong treatment relative to the control. However, in Shu Xue Tong-treated rat flap, Notch1 and Dll4 levels were significantly reduced. Conclusions: These results demonstrate the beneficial action of Shu Xue Tong on random skin flap survival and suggest that its mechanism of action involves the promotion of angiogenesis via the VEGF-Notch1/Dll4 signaling pathway.http://dx.doi.org/10.1080/08941939.2018.1551948shu xue tong injectionrandom skin flapvegfratnotchdll4 |
| spellingShingle | Chaoyang Qi Yuting Lin Dingsheng Lin The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway Journal of Investigative Surgery shu xue tong injection random skin flap vegf rat notch dll4 |
| title | The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway |
| title_full | The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway |
| title_fullStr | The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway |
| title_full_unstemmed | The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway |
| title_short | The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway |
| title_sort | effect of shu xue tong treatment on random skin flap survival via the vegf notch dll4 signaling pathway |
| topic | shu xue tong injection random skin flap vegf rat notch dll4 |
| url | http://dx.doi.org/10.1080/08941939.2018.1551948 |
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