Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis
Insulin resistance plays an important role in the pathogenesis of polycystic ovarian syndrome (PCOS). Calpain10 (CAPN10) gene was the first identified susceptibility gene for type 2 diabetes mellitus and closely related to insulin sensitivity. A lot of research attention has been attracted on the re...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1153960/full |
| _version_ | 1797729264535076864 |
|---|---|
| author | Yamei Li Yamei Li Ting Han Yingxia Wang Jie Gao Jianglin Zhang Yinglan Wu Jiayou Luo |
| author_facet | Yamei Li Yamei Li Ting Han Yingxia Wang Jie Gao Jianglin Zhang Yinglan Wu Jiayou Luo |
| author_sort | Yamei Li |
| collection | DOAJ |
| description | Insulin resistance plays an important role in the pathogenesis of polycystic ovarian syndrome (PCOS). Calpain10 (CAPN10) gene was the first identified susceptibility gene for type 2 diabetes mellitus and closely related to insulin sensitivity. A lot of research attention has been attracted on the relationship between CAPN10 polymorphisms and PCOS risk, but they didn’t reach a consistent conclusion. We therefore performed this systematic review and meta-analysis to assess the association of CAPN10 common variants with PCOS susceptibility. A total of 21 studies were eligible for inclusion. Meta-analyses were done for 5 variants that had at least two data sources: UCSNP-19, -43, −44, −56 and −63. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under five genetic models. Subgroup analyses by ethnicity, PCOS diagnostic criteria, and source of controls were conducted. Moreover, false-positive report probability (FPRP) test and trial sequential analysis (TSA) were performed to assess the significant associations. The results showed a possible negative association between UCSNP-19 and PCOS risk (ins/ins vs. del/del + del/ins: OR = 0.84, 95% CI: 0.72–0.98). In subgroup analyses, FPRP test indicated that noteworthy associations were observed in mixed ethnicities for UCSNP-43 (A vs. G: OR = 1.81, 95% CI: 1.17-2.79; AA + AG vs. GG: OR = 2.14, 95% CI: 1.20-3.80) and in Asians for UCSNP-44 (CC vs. TT: OR = 2.07, 95% CI: 1.21-3.51; CC vs. CT + TT: OR = 2.19, 95% CI: 1.31-3.69), but TSA plots showed that the accumulated sample sizes of these associations were insufficient to draw firm conclusions. In summary, our study suggested that UCSNP-19, UCSNP-43, and UCSNP-44 in CAPN10 gene may be involved in PCOS susceptibility. These findings warrant further studies. |
| first_indexed | 2024-03-12T11:26:40Z |
| format | Article |
| id | doaj.art-d91285b71f1a47d6971ae7ee927077af |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-12T11:26:40Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-d91285b71f1a47d6971ae7ee927077af2023-09-01T08:15:46ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-09-011410.3389/fgene.2023.11539601153960Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysisYamei Li0Yamei Li1Ting Han2Yingxia Wang3Jie Gao4Jianglin Zhang5Yinglan Wu6Jiayou Luo7NHC Key Laboratory for Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, ChinaDepartment of Women Health Care, Hunan Provincial Maternal and Child Healthcare Hospital, Changsha, ChinaDepartment of Women Health Care, Hunan Provincial Maternal and Child Healthcare Hospital, Changsha, ChinaDepartment of Women Health Care, Hunan Provincial Maternal and Child Healthcare Hospital, Changsha, ChinaDepartment of Women Health Care, Hunan Provincial Maternal and Child Healthcare Hospital, Changsha, ChinaDepartment of Women Health Care, Hunan Provincial Maternal and Child Healthcare Hospital, Changsha, ChinaDepartment of Women Health Care, Hunan Provincial Maternal and Child Healthcare Hospital, Changsha, ChinaDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, ChinaInsulin resistance plays an important role in the pathogenesis of polycystic ovarian syndrome (PCOS). Calpain10 (CAPN10) gene was the first identified susceptibility gene for type 2 diabetes mellitus and closely related to insulin sensitivity. A lot of research attention has been attracted on the relationship between CAPN10 polymorphisms and PCOS risk, but they didn’t reach a consistent conclusion. We therefore performed this systematic review and meta-analysis to assess the association of CAPN10 common variants with PCOS susceptibility. A total of 21 studies were eligible for inclusion. Meta-analyses were done for 5 variants that had at least two data sources: UCSNP-19, -43, −44, −56 and −63. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under five genetic models. Subgroup analyses by ethnicity, PCOS diagnostic criteria, and source of controls were conducted. Moreover, false-positive report probability (FPRP) test and trial sequential analysis (TSA) were performed to assess the significant associations. The results showed a possible negative association between UCSNP-19 and PCOS risk (ins/ins vs. del/del + del/ins: OR = 0.84, 95% CI: 0.72–0.98). In subgroup analyses, FPRP test indicated that noteworthy associations were observed in mixed ethnicities for UCSNP-43 (A vs. G: OR = 1.81, 95% CI: 1.17-2.79; AA + AG vs. GG: OR = 2.14, 95% CI: 1.20-3.80) and in Asians for UCSNP-44 (CC vs. TT: OR = 2.07, 95% CI: 1.21-3.51; CC vs. CT + TT: OR = 2.19, 95% CI: 1.31-3.69), but TSA plots showed that the accumulated sample sizes of these associations were insufficient to draw firm conclusions. In summary, our study suggested that UCSNP-19, UCSNP-43, and UCSNP-44 in CAPN10 gene may be involved in PCOS susceptibility. These findings warrant further studies.https://www.frontiersin.org/articles/10.3389/fgene.2023.1153960/fullCalpain10 genepolymorphismpolycystic ovarian syndromesystematic reviewmeta-analysisfalse-positive report probability |
| spellingShingle | Yamei Li Yamei Li Ting Han Yingxia Wang Jie Gao Jianglin Zhang Yinglan Wu Jiayou Luo Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis Frontiers in Genetics Calpain10 gene polymorphism polycystic ovarian syndrome systematic review meta-analysis false-positive report probability |
| title | Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis |
| title_full | Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis |
| title_fullStr | Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis |
| title_full_unstemmed | Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis |
| title_short | Association of Calpain10 polymorphisms with polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis with trial sequential analysis |
| title_sort | association of calpain10 polymorphisms with polycystic ovarian syndrome susceptibility a systematic review and meta analysis with trial sequential analysis |
| topic | Calpain10 gene polymorphism polycystic ovarian syndrome systematic review meta-analysis false-positive report probability |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1153960/full |
| work_keys_str_mv | AT yameili associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT yameili associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT tinghan associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT yingxiawang associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT jiegao associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT jianglinzhang associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT yinglanwu associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT jiayouluo associationofcalpain10polymorphismswithpolycysticovariansyndromesusceptibilityasystematicreviewandmetaanalysiswithtrialsequentialanalysis |