Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility
Background and Aims: Nicotine dependence (ND)-induced anxiety might be modulated by genetic polymorphisms. The gene-by-environment interaction can be fitted into the diathesis-stress and differential susceptibility models. Nevertheless, knowledge of the interaction between adiponectin (ADPN) polymor...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-11-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711309 |
| _version_ | 1811314230872244224 |
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| author | Xudong Zhao Fenzan Wu Guanghui Shen Wei Wang Shizhuo Yang Yueling Hu Yuyu Wu Kewei Xu Lili Zhao Xinhua Shen Yanlong Liu Fan Wang Li Chen |
| author_facet | Xudong Zhao Fenzan Wu Guanghui Shen Wei Wang Shizhuo Yang Yueling Hu Yuyu Wu Kewei Xu Lili Zhao Xinhua Shen Yanlong Liu Fan Wang Li Chen |
| author_sort | Xudong Zhao |
| collection | DOAJ |
| description | Background and Aims: Nicotine dependence (ND)-induced anxiety might be modulated by genetic polymorphisms. The gene-by-environment interaction can be fitted into the diathesis-stress and differential susceptibility models. Nevertheless, knowledge of the interaction between adiponectin (ADPN) polymorphisms and ND on the incident mental disorder is currently scarce. This study aims to understand the role of ADPN rs266729 on anxiety in patients with ND while elucidating the psychology model and the various reactions across genotypes. Methods: We included 315 Chinese males with confirmed ND, measured using the Fagerstrom test for nicotine dependence (FTND). Anxiety was assessed using the Self-rating Anxiety Scale. Genomic DNA was extracted and genotyped from peripheral blood. Hierarchical regression models were used to test the interactions. Results: There was a significant interaction between ADPN rs266729 and ND (β = –0.19, p < 0.05). The CC homozygote was more likely to be affected by ND-induced anxiety (β = 0.14, t = 4.43, p < 0.01). Re-parameterized regression models revealed that the interaction between ADPN rs266729 and ND could fit the strong differential susceptibility model (R2 = 0.05, p < 0.001). Conclusions: ADPN rs266729 was correlated with susceptibility to anxiety symptoms among male adults with ND and could fit the differential susceptibility model. The CC homozygote of rs266729 was a plasticity factor that increased anxiety symptoms in individuals with ND. |
| first_indexed | 2024-04-13T11:08:12Z |
| format | Article |
| id | doaj.art-d9142de61a6340859c85b040b27941a7 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-13T11:08:12Z |
| publishDate | 2022-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-d9142de61a6340859c85b040b27941a72022-12-22T02:49:13ZengIMR PressFrontiers in Bioscience-Landmark2768-67012022-11-01271130910.31083/j.fbl2711309S2768-6701(22)00672-4Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety SusceptibilityXudong Zhao0Fenzan Wu1Guanghui Shen2Wei Wang3Shizhuo Yang4Yueling Hu5Yuyu Wu6Kewei Xu7Lili Zhao8Xinhua Shen9Yanlong Liu10Fan Wang11Li Chen12Huzhou Third Municipal Hospital, The Affiliated Hospital of Wenzhou Medical University, 313000 Huzhou, Zhejiang, ChinaLaboratory of Translational Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, 315300 Ningbo, Zhejiang, ChinaSchool of Mental Health, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaSchool of Mental Health, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaSchool of Pharmacy, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaSchool of Mental Health, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaSchool of Mental Health, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaSchool of Mental Health, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaHuzhou Third Municipal Hospital, The Affiliated Hospital of Wenzhou Medical University, 313000 Huzhou, Zhejiang, ChinaHuzhou Third Municipal Hospital, The Affiliated Hospital of Wenzhou Medical University, 313000 Huzhou, Zhejiang, ChinaSchool of Mental Health, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaBeijing Hui-Long-Guan Hospital, Peking University, 100096 Beijing, ChinaThe Affiliated Kangning Hospital, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, ChinaBackground and Aims: Nicotine dependence (ND)-induced anxiety might be modulated by genetic polymorphisms. The gene-by-environment interaction can be fitted into the diathesis-stress and differential susceptibility models. Nevertheless, knowledge of the interaction between adiponectin (ADPN) polymorphisms and ND on the incident mental disorder is currently scarce. This study aims to understand the role of ADPN rs266729 on anxiety in patients with ND while elucidating the psychology model and the various reactions across genotypes. Methods: We included 315 Chinese males with confirmed ND, measured using the Fagerstrom test for nicotine dependence (FTND). Anxiety was assessed using the Self-rating Anxiety Scale. Genomic DNA was extracted and genotyped from peripheral blood. Hierarchical regression models were used to test the interactions. Results: There was a significant interaction between ADPN rs266729 and ND (β = –0.19, p < 0.05). The CC homozygote was more likely to be affected by ND-induced anxiety (β = 0.14, t = 4.43, p < 0.01). Re-parameterized regression models revealed that the interaction between ADPN rs266729 and ND could fit the strong differential susceptibility model (R2 = 0.05, p < 0.001). Conclusions: ADPN rs266729 was correlated with susceptibility to anxiety symptoms among male adults with ND and could fit the differential susceptibility model. The CC homozygote of rs266729 was a plasticity factor that increased anxiety symptoms in individuals with ND.https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711309nicotine dependence (nd)anxietypolymorphismadiponectindifferential susceptibility |
| spellingShingle | Xudong Zhao Fenzan Wu Guanghui Shen Wei Wang Shizhuo Yang Yueling Hu Yuyu Wu Kewei Xu Lili Zhao Xinhua Shen Yanlong Liu Fan Wang Li Chen Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility Frontiers in Bioscience-Landmark nicotine dependence (nd) anxiety polymorphism adiponectin differential susceptibility |
| title | Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility |
| title_full | Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility |
| title_fullStr | Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility |
| title_full_unstemmed | Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility |
| title_short | Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility |
| title_sort | adiponectin rs266729 polymorphism and nicotine dependence interaction genetic investigations on the anxiety susceptibility |
| topic | nicotine dependence (nd) anxiety polymorphism adiponectin differential susceptibility |
| url | https://www.imrpress.com/journal/FBL/27/11/10.31083/j.fbl2711309 |
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