Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study
Background: Heart transplantation represents the treatment for patients with end-stage heart failure (HF) being symptomatic despite optimal medical therapy. We investigated the role of NMR (neutrophil-to-monocyte ratio), NLR (neutrophil-to-lymphocyte ratio), NPR (neutrophil-to-platelet ratio), NWR (...
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MDPI AG
2023-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/2/81 |
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| author | Dragos-Florin Baba Horatiu Suciu Calin Avram Manuela Gyorgy Alina Danilesco Laurentiu Huma Ileana Anca Sin |
| author_facet | Dragos-Florin Baba Horatiu Suciu Calin Avram Manuela Gyorgy Alina Danilesco Laurentiu Huma Ileana Anca Sin |
| author_sort | Dragos-Florin Baba |
| collection | DOAJ |
| description | Background: Heart transplantation represents the treatment for patients with end-stage heart failure (HF) being symptomatic despite optimal medical therapy. We investigated the role of NMR (neutrophil-to-monocyte ratio), NLR (neutrophil-to-lymphocyte ratio), NPR (neutrophil-to-platelet ratio), NWR (neutrophil-to-white cells ratio), MLR (monocyte-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio), MWR (neutrophil-to-white cells ratio), and LWR (lymphocyte-to-white cells ratio) at the same cut-off values previously studied, to predict complications after heart transplant within 2 months after surgery. Methods: From May 2014 to January 2021, was included 38 patients in our study from the Cardiovascular and Transplant Emergency Institute of Târgu Mureș. Results: Preoperative NMR > 8.9 (OR: 70.71, 95% CI: 3.39–1473.64; <i>p</i> = 0.006) was a risk factor for the apparition of post-operative paroxysmal atrial fibrillation (Afib). In contrast, preoperative MWR > 0.09 (OR: 0.04, 95% CI: 0.003–0.58; <i>p</i> = 0.0182) represented a protective factor against AFib, but being the risk of complications of any cause (OR: 14.74, 95% CI: 1.05–206.59, <i>p</i> = 0.0458). Conclusion: Preoperative elevated levels of NMR were associated with the apparition of documented AFib, with high levels of MWR as a protective factor. High MWR was a risk factor in developing complications of any cause in the first 2 months after heart transplantation. |
| first_indexed | 2024-03-11T08:39:07Z |
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| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-11T08:39:07Z |
| publishDate | 2023-02-01 |
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| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-d914b3ee57c44c078316a726643d20042023-11-16T21:16:45ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-02-011028110.3390/jcdd10020081Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective StudyDragos-Florin Baba0Horatiu Suciu1Calin Avram2Manuela Gyorgy3Alina Danilesco4Laurentiu Huma5Ileana Anca Sin6Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, RomaniaEmergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, RomaniaDepartment of Medical Informatics and Biostatistics, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaDepartment of Psychology, Dimitrie Cantemir University, 999032 Bucharest, RomaniaDepartment of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaEmergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, RomaniaDepartment of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaBackground: Heart transplantation represents the treatment for patients with end-stage heart failure (HF) being symptomatic despite optimal medical therapy. We investigated the role of NMR (neutrophil-to-monocyte ratio), NLR (neutrophil-to-lymphocyte ratio), NPR (neutrophil-to-platelet ratio), NWR (neutrophil-to-white cells ratio), MLR (monocyte-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio), MWR (neutrophil-to-white cells ratio), and LWR (lymphocyte-to-white cells ratio) at the same cut-off values previously studied, to predict complications after heart transplant within 2 months after surgery. Methods: From May 2014 to January 2021, was included 38 patients in our study from the Cardiovascular and Transplant Emergency Institute of Târgu Mureș. Results: Preoperative NMR > 8.9 (OR: 70.71, 95% CI: 3.39–1473.64; <i>p</i> = 0.006) was a risk factor for the apparition of post-operative paroxysmal atrial fibrillation (Afib). In contrast, preoperative MWR > 0.09 (OR: 0.04, 95% CI: 0.003–0.58; <i>p</i> = 0.0182) represented a protective factor against AFib, but being the risk of complications of any cause (OR: 14.74, 95% CI: 1.05–206.59, <i>p</i> = 0.0458). Conclusion: Preoperative elevated levels of NMR were associated with the apparition of documented AFib, with high levels of MWR as a protective factor. High MWR was a risk factor in developing complications of any cause in the first 2 months after heart transplantation.https://www.mdpi.com/2308-3425/10/2/81neutrophil-to-monocyte ratiomonocyte-to-white cells ratioinflammationatrial fibrillationheart transplant |
| spellingShingle | Dragos-Florin Baba Horatiu Suciu Calin Avram Manuela Gyorgy Alina Danilesco Laurentiu Huma Ileana Anca Sin Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study Journal of Cardiovascular Development and Disease neutrophil-to-monocyte ratio monocyte-to-white cells ratio inflammation atrial fibrillation heart transplant |
| title | Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study |
| title_full | Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study |
| title_fullStr | Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study |
| title_full_unstemmed | Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study |
| title_short | Elevated Levels of Neutrophil-to Monocyte Ratio Are Associated with the Initiation of Paroxysmal Documented Atrial Fibrillation in the First Two Months after Heart Transplantation: A Uni-Institutional Retrospective Study |
| title_sort | elevated levels of neutrophil to monocyte ratio are associated with the initiation of paroxysmal documented atrial fibrillation in the first two months after heart transplantation a uni institutional retrospective study |
| topic | neutrophil-to-monocyte ratio monocyte-to-white cells ratio inflammation atrial fibrillation heart transplant |
| url | https://www.mdpi.com/2308-3425/10/2/81 |
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