Relationship between pregnancy-associated variables and breast cancer risk: A systematic review
Introduction: Globally, breast cancer is the most common malignancy causing extensive mortality in women. In most cases, there is no known risk factor for breast cancer. Extensive hormonal changes that occur during pregnancy appear to be involved in the etiology of breast cancer. Since identifying r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
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Mashhad University of Medical Sciences
2018-04-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_10716_df8bff13c07672818686e6de72e0db4c.pdf |
| _version_ | 1811328556706299904 |
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| author | Zohreh Yeganeh Zohre Sheikhan Nourossadat Kariman Parasto Hajian Malihe Nasiri Narges Mirzadeh |
| author_facet | Zohreh Yeganeh Zohre Sheikhan Nourossadat Kariman Parasto Hajian Malihe Nasiri Narges Mirzadeh |
| author_sort | Zohreh Yeganeh |
| collection | DOAJ |
| description | Introduction: Globally, breast cancer is the most common malignancy causing extensive mortality in women. In most cases, there is no known risk factor for breast cancer. Extensive hormonal changes that occur during pregnancy appear to be involved in the etiology of breast cancer. Since identifying risk factors helps with primary prevention and early diagnosis of breast cancer, this study was performed to systematically review studies about pregnancy-related variables and the risk of breast cancer in Iran and worldwide. Methods: In this systematic review, we searched PubMed, Google Scholar, Scopus, SID, and Science Direct databases using keywords of “pregnancy-related variables” and “breast cancer” to retrieve articles published during 2000-2017. Then, those articles that obtained a score of ≥ 6 based on the Newcastle–Ottawa Scale were entered to the study. The results were reported qualitatively. Results: Fifty articles consisting of 26 case-controls and 24 cohort articles, which met the inclusion criteria, were investigated. Our evaluations indicated that among the factors examined, abortion and preeclampsia had a stronger relationship with breast cancer. Conclusion: History of abortion seems to increase the risk of breast cancer. Also, history of preeclampsia plays a protective role in breast cancer. Further studies are needed to examine the relationship of gestational diabetes and multiple gestations with breast cancer. |
| first_indexed | 2024-04-13T15:27:11Z |
| format | Article |
| id | doaj.art-d914d9c307664e68a22208d25e70f606 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-13T15:27:11Z |
| publishDate | 2018-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-d914d9c307664e68a22208d25e70f6062022-12-22T02:41:28ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632018-04-01212859710.22038/ijogi.2018.1071610716Relationship between pregnancy-associated variables and breast cancer risk: A systematic reviewZohreh Yeganeh0Zohre Sheikhan1Nourossadat Kariman2Parasto Hajian3Malihe Nasiri4Narges Mirzadeh5M.Sc. Student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Instructor, Department of Midwifery, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Assistant Professor, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Radiotherapist-oncologist, Department of Radiotherapy and Oncology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Assistant Professor, Department of Biostatics, Faculty of Paramedics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.M.Sc. Student of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Introduction: Globally, breast cancer is the most common malignancy causing extensive mortality in women. In most cases, there is no known risk factor for breast cancer. Extensive hormonal changes that occur during pregnancy appear to be involved in the etiology of breast cancer. Since identifying risk factors helps with primary prevention and early diagnosis of breast cancer, this study was performed to systematically review studies about pregnancy-related variables and the risk of breast cancer in Iran and worldwide. Methods: In this systematic review, we searched PubMed, Google Scholar, Scopus, SID, and Science Direct databases using keywords of “pregnancy-related variables” and “breast cancer” to retrieve articles published during 2000-2017. Then, those articles that obtained a score of ≥ 6 based on the Newcastle–Ottawa Scale were entered to the study. The results were reported qualitatively. Results: Fifty articles consisting of 26 case-controls and 24 cohort articles, which met the inclusion criteria, were investigated. Our evaluations indicated that among the factors examined, abortion and preeclampsia had a stronger relationship with breast cancer. Conclusion: History of abortion seems to increase the risk of breast cancer. Also, history of preeclampsia plays a protective role in breast cancer. Further studies are needed to examine the relationship of gestational diabetes and multiple gestations with breast cancer.https://ijogi.mums.ac.ir/article_10716_df8bff13c07672818686e6de72e0db4c.pdfbreast cancerabortionpreeclampsiagestational diabetesmultiple gestationssystematic review |
| spellingShingle | Zohreh Yeganeh Zohre Sheikhan Nourossadat Kariman Parasto Hajian Malihe Nasiri Narges Mirzadeh Relationship between pregnancy-associated variables and breast cancer risk: A systematic review Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān breast cancer abortion preeclampsia gestational diabetes multiple gestations systematic review |
| title | Relationship between pregnancy-associated variables and breast cancer risk: A systematic review |
| title_full | Relationship between pregnancy-associated variables and breast cancer risk: A systematic review |
| title_fullStr | Relationship between pregnancy-associated variables and breast cancer risk: A systematic review |
| title_full_unstemmed | Relationship between pregnancy-associated variables and breast cancer risk: A systematic review |
| title_short | Relationship between pregnancy-associated variables and breast cancer risk: A systematic review |
| title_sort | relationship between pregnancy associated variables and breast cancer risk a systematic review |
| topic | breast cancer abortion preeclampsia gestational diabetes multiple gestations systematic review |
| url | https://ijogi.mums.ac.ir/article_10716_df8bff13c07672818686e6de72e0db4c.pdf |
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