Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trial
Introduction: Regarding the safety of Ondansetronecompared to other anti-shivering drugs, its lower side effects and the contradictory results of its use in the prevention of postoperative shivering, this study was performed with aim to evaluate the effect of preoperative intravenous administration...
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| Format: | Article |
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Mashhad University of Medical Sciences
2020-06-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_16283_e29efb8cfd01a890bed75a4471056655.pdf |
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| author | Farnaz Moslemi Rayhaneh Abri Sardroudi Sevda Arashazad Mohadeseh BijanPour Maryam Sheydaei |
| author_facet | Farnaz Moslemi Rayhaneh Abri Sardroudi Sevda Arashazad Mohadeseh BijanPour Maryam Sheydaei |
| author_sort | Farnaz Moslemi |
| collection | DOAJ |
| description | Introduction: Regarding the safety of Ondansetronecompared to other anti-shivering drugs, its lower side effects and the contradictory results of its use in the prevention of postoperative shivering, this study was performed with aim to evaluate the effect of preoperative intravenous administration of Ondansetroneon prevention of anesthesia-induced shivering in gynecological surgeries.
Methods: This randomized clinical trial study was conducted in 2019 with the participation of 100 women in Alzahra Hospital-Tabriz. Patients were randomly divided into two groups. The intervention group received 2 ml (8 mg) of ondansetroneand the control group received 2 ml of normal saline. The shivering intensity in each patient was recorded according to the shiver severity criterion (LAS). Data were analyzed by SPSS software (version 22) and Chi-square test. P <0.05 was considered statistically significant.
Results: Comparison of the number of cases with shivering after anesthesia indicated that 6 (12%) of the ondansetronegroup and 21 (42%) of the control group had shivering intensity >3 that two groups had statistically significant difference (p= 0.001)
Conclusion: Ondansetrone, as one of the 5-HT3 antagonists, can be effective in preventing shivering after general anesthesia in gynecological surgeries, but it cannot completely inhibit shivering. |
| first_indexed | 2024-04-11T07:07:16Z |
| format | Article |
| id | doaj.art-d916a333941b4d61a1d44e028efa7fac |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T07:07:16Z |
| publishDate | 2020-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-d916a333941b4d61a1d44e028efa7fac2022-12-22T04:38:22ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632020-06-0123481410.22038/ijogi.2020.1628316283Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trialFarnaz Moslemi0Rayhaneh Abri Sardroudi1Sevda Arashazad2Mohadeseh BijanPour3Maryam Sheydaei4Associate Professor, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranResident, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.B.Sc. of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Resident, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Introduction: Regarding the safety of Ondansetronecompared to other anti-shivering drugs, its lower side effects and the contradictory results of its use in the prevention of postoperative shivering, this study was performed with aim to evaluate the effect of preoperative intravenous administration of Ondansetroneon prevention of anesthesia-induced shivering in gynecological surgeries. Methods: This randomized clinical trial study was conducted in 2019 with the participation of 100 women in Alzahra Hospital-Tabriz. Patients were randomly divided into two groups. The intervention group received 2 ml (8 mg) of ondansetroneand the control group received 2 ml of normal saline. The shivering intensity in each patient was recorded according to the shiver severity criterion (LAS). Data were analyzed by SPSS software (version 22) and Chi-square test. P <0.05 was considered statistically significant. Results: Comparison of the number of cases with shivering after anesthesia indicated that 6 (12%) of the ondansetronegroup and 21 (42%) of the control group had shivering intensity >3 that two groups had statistically significant difference (p= 0.001) Conclusion: Ondansetrone, as one of the 5-HT3 antagonists, can be effective in preventing shivering after general anesthesia in gynecological surgeries, but it cannot completely inhibit shivering.https://ijogi.mums.ac.ir/article_16283_e29efb8cfd01a890bed75a4471056655.pdfgeneral anesthesiagynecologic surgeriesondansetroneshivering |
| spellingShingle | Farnaz Moslemi Rayhaneh Abri Sardroudi Sevda Arashazad Mohadeseh BijanPour Maryam Sheydaei Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trial Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān general anesthesia gynecologic surgeries ondansetrone shivering |
| title | Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trial |
| title_full | Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trial |
| title_fullStr | Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trial |
| title_full_unstemmed | Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trial |
| title_short | Effect of intravenous administration of Ondansetrone on prevention of anesthesia-induced shivering in gynecologic surgeries: a randomized clinical trial |
| title_sort | effect of intravenous administration of ondansetrone on prevention of anesthesia induced shivering in gynecologic surgeries a randomized clinical trial |
| topic | general anesthesia gynecologic surgeries ondansetrone shivering |
| url | https://ijogi.mums.ac.ir/article_16283_e29efb8cfd01a890bed75a4471056655.pdf |
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