Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity

Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity

Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling. One such enzyme is diacylglycerol kinase θ (DGKθ), which produces phosphatidic acid (PtdOH) that generates negative membrane curvatur...

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Bibliographic Details
Main Authors: Casey N. Barber, Hana L. Goldschmidt, Qianqian Ma, Lauren R. Devine, Robert N. Cole, Richard L. Huganir, Daniel M. Raben
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
neurotransmission
synapse
lipids
synaptic vesicles
Syt1
APEX2
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2022.855673/full

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