The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis
Myeloid cells are crucial for the host control of a Mycobacterium tuberculosis (M.tb) infection, however the adverse role of specific myeloid subsets has increasingly been appreciated. The relevance of such cells in therapeutic strategies and predictive/prognostic algorithms is to promote interest i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00917/full |
| _version_ | 1811269710391541760 |
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| author | Tandeka Magcwebeba Anca Dorhoi Anca Dorhoi Anca Dorhoi Nelita du Plessis |
| author_facet | Tandeka Magcwebeba Anca Dorhoi Anca Dorhoi Anca Dorhoi Nelita du Plessis |
| author_sort | Tandeka Magcwebeba |
| collection | DOAJ |
| description | Myeloid cells are crucial for the host control of a Mycobacterium tuberculosis (M.tb) infection, however the adverse role of specific myeloid subsets has increasingly been appreciated. The relevance of such cells in therapeutic strategies and predictive/prognostic algorithms is to promote interest in regulatory myeloid cells in tuberculosis (TB). Myeloid-derived suppressor cells (MDSC) are a heterogeneous collection of phagocytes comprised of monocytic- and polymorphonuclear cells that exhibit a potent suppression of innate- and adaptive immune responses. Accumulation of MDSC under pathological conditions associated with chronic inflammation, most notably cancer, has been well-described. Evidence supporting the involvement of MDSC in TB is increasing, yet their significance in this infection continues to be viewed with skepticism, primarily due to their complex nature and the lack of genetic evidence unequivocally discriminating these cells from other terminally differentiated myeloid populations. Here we highlight recent advances in MDSC characterization and summarize findings on the TB-induced hematopoietic shift associated with MDSC expansion. Lastly, the mechanisms of MDSC-mediated disease progression and future research avenues in the context of TB therapy and prophylaxis are discussed. |
| first_indexed | 2024-04-12T21:46:56Z |
| format | Article |
| id | doaj.art-d9189edde40649f18d79267b2e4e56f1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T21:46:56Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d9189edde40649f18d79267b2e4e56f12022-12-22T03:15:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00917454559The Emerging Role of Myeloid-Derived Suppressor Cells in TuberculosisTandeka Magcwebeba0Anca Dorhoi1Anca Dorhoi2Anca Dorhoi3Nelita du Plessis4Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, South African MRC Centre for Tuberculosis Research, DST and NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, Stellenbosch, South AfricaInstitute of Immunology, Friedrich-Loeffler-Institut, Greifswald, GermanyFaculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, GermanyDepartment of Immunology, Max Planck Institute for Infection Biology, Berlin, GermanyDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, South African MRC Centre for Tuberculosis Research, DST and NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, Stellenbosch, South AfricaMyeloid cells are crucial for the host control of a Mycobacterium tuberculosis (M.tb) infection, however the adverse role of specific myeloid subsets has increasingly been appreciated. The relevance of such cells in therapeutic strategies and predictive/prognostic algorithms is to promote interest in regulatory myeloid cells in tuberculosis (TB). Myeloid-derived suppressor cells (MDSC) are a heterogeneous collection of phagocytes comprised of monocytic- and polymorphonuclear cells that exhibit a potent suppression of innate- and adaptive immune responses. Accumulation of MDSC under pathological conditions associated with chronic inflammation, most notably cancer, has been well-described. Evidence supporting the involvement of MDSC in TB is increasing, yet their significance in this infection continues to be viewed with skepticism, primarily due to their complex nature and the lack of genetic evidence unequivocally discriminating these cells from other terminally differentiated myeloid populations. Here we highlight recent advances in MDSC characterization and summarize findings on the TB-induced hematopoietic shift associated with MDSC expansion. Lastly, the mechanisms of MDSC-mediated disease progression and future research avenues in the context of TB therapy and prophylaxis are discussed.https://www.frontiersin.org/article/10.3389/fimmu.2019.00917/fullmyeloid-derived suppressor cellsMycobacterium tuberculosisinfectious diseaseimmunosuppressioninnate immunity |
| spellingShingle | Tandeka Magcwebeba Anca Dorhoi Anca Dorhoi Anca Dorhoi Nelita du Plessis The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis Frontiers in Immunology myeloid-derived suppressor cells Mycobacterium tuberculosis infectious disease immunosuppression innate immunity |
| title | The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis |
| title_full | The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis |
| title_fullStr | The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis |
| title_full_unstemmed | The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis |
| title_short | The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis |
| title_sort | emerging role of myeloid derived suppressor cells in tuberculosis |
| topic | myeloid-derived suppressor cells Mycobacterium tuberculosis infectious disease immunosuppression innate immunity |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00917/full |
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