Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig Skin

Background: Regarding to the skin damages caused by the ultraviolet ray of sun and the need for protective materials against these mal effects, Silymarin was evaluated for the porpose. Objective: In this study, by histopathology studies and surveying the clinical symptoms the external use of an herb...

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Main Authors: AH Jamshidi, HR Ahmadi - Ashtiani, MM Naderi, S Bokaei, B Gholamhouseyni
Format: Article
Language:English
Published: Institue of Medicinal Plants, ACECR 2007-09-01
Series:Journal of Medicinal Plants
Subjects:
Online Access:http://jmp.ir/article-1-595-en.html
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author AH Jamshidi
HR Ahmadi - Ashtiani
MM Naderi
S Bokaei
B Gholamhouseyni
author_facet AH Jamshidi
HR Ahmadi - Ashtiani
MM Naderi
S Bokaei
B Gholamhouseyni
author_sort AH Jamshidi
collection DOAJ
description Background: Regarding to the skin damages caused by the ultraviolet ray of sun and the need for protective materials against these mal effects, Silymarin was evaluated for the porpose. Objective: In this study, by histopathology studies and surveying the clinical symptoms the external use of an herbaceous (herbal) substance, Silymarin, in protecting the mal effects of ultraviolet ray has been evaluated. Methods: For the study 60 albino hamsters with same age and gender has been selected and they divided in two groups (each group 30 hamsters) randomly. The hair on the back of all animals shaved in an area about 2 square centimeters. The first group gets 9 miligram Silymarin with 20 micro liter acetone topically, and the second group gets only 20 micro liter acetone topically. Then both groups for 45 days exposed to ultra violet ray, 180milijoule/cm2 each day. Results and Conclusion: The results of clinical and histopathologic surveys show that topical usage of Silymarin has considerable protective effects against the mal effects of ultra violet ray on skin and this can be a promise for using this herbaceous substance as a topical sun protects substance.
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spelling doaj.art-d9193525763a478e869a4fde2b85f5702022-12-21T21:59:11ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582007-09-016238996Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig SkinAH Jamshidi0HR Ahmadi - Ashtiani1MM Naderi2S Bokaei3B Gholamhouseyni4 Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, FDLRC and Institute of Medicinal Plants, ACECR, Tehran, Iran Clinical Biochemistry, Tehran, Tarbiat-e-Modarres University, School of Medical Science, Department of Clinical Biochemistry, Tehran, Iran Small Animal Internal Medicine, Tehran, Islamic Azad University (Research and Science Branch), Veterinary Faculty, Department of Small Animal Internal Medicine, Tehran, Iran Epidemiology, Tehran, Tehran University, Veterinary Faculty, Department of food hygiene, Epidemiology division, Tehran, Iran Veterinary Pathology, Karaj, Islamic Azad University (Karaj Branch), Veterinary Faculty, Department of Pathobiology, Karaj, Iran Background: Regarding to the skin damages caused by the ultraviolet ray of sun and the need for protective materials against these mal effects, Silymarin was evaluated for the porpose. Objective: In this study, by histopathology studies and surveying the clinical symptoms the external use of an herbaceous (herbal) substance, Silymarin, in protecting the mal effects of ultraviolet ray has been evaluated. Methods: For the study 60 albino hamsters with same age and gender has been selected and they divided in two groups (each group 30 hamsters) randomly. The hair on the back of all animals shaved in an area about 2 square centimeters. The first group gets 9 miligram Silymarin with 20 micro liter acetone topically, and the second group gets only 20 micro liter acetone topically. Then both groups for 45 days exposed to ultra violet ray, 180milijoule/cm2 each day. Results and Conclusion: The results of clinical and histopathologic surveys show that topical usage of Silymarin has considerable protective effects against the mal effects of ultra violet ray on skin and this can be a promise for using this herbaceous substance as a topical sun protects substance.http://jmp.ir/article-1-595-en.htmlsilymarinskinu.v.clinical findinghistopathologyguinea pig
spellingShingle AH Jamshidi
HR Ahmadi - Ashtiani
MM Naderi
S Bokaei
B Gholamhouseyni
Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig Skin
Journal of Medicinal Plants
silymarin
skin
u.v.
clinical finding
histopathology
guinea pig
title Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig Skin
title_full Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig Skin
title_fullStr Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig Skin
title_full_unstemmed Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig Skin
title_short Study on Effects of Topical Use of Silybum marianum Extract (Silymarin) on U.V. Irradiated Guinea Pig Skin
title_sort study on effects of topical use of silybum marianum extract silymarin on u v irradiated guinea pig skin
topic silymarin
skin
u.v.
clinical finding
histopathology
guinea pig
url http://jmp.ir/article-1-595-en.html
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