TRA2: The dominant power of alternative splicing in tumors
The dysregulation of alternative splicing (AS) is frequently found in cancer and considered as key markers for cancer progression and therapy. Transformer 2 (TRA2), a nuclear RNA binding protein, consists of transformer 2 alpha homolog (TRA2A) and transformer 2 beta homolog (TRA2B), and plays a role...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023027238 |
| _version_ | 1827957266839502848 |
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| author | Jiancheng Xue Tie Ma Xiaowen Zhang |
| author_facet | Jiancheng Xue Tie Ma Xiaowen Zhang |
| author_sort | Jiancheng Xue |
| collection | DOAJ |
| description | The dysregulation of alternative splicing (AS) is frequently found in cancer and considered as key markers for cancer progression and therapy. Transformer 2 (TRA2), a nuclear RNA binding protein, consists of transformer 2 alpha homolog (TRA2A) and transformer 2 beta homolog (TRA2B), and plays a role in the regulation of pre-mRNA splicing. Growing evidence has been provided that TRA2A and TRA2B are dysregulated in several types of tumors, and participate in the regulation of proliferation, migration, invasion, and chemotherapy resistance in cancer cells through alteration of AS of cancer-related genes. In this review, we highlight the role of TRA2 in tumorigenesis and metastasis, and discuss potential molecular mechanisms how TRA2 influences tumorigenesis and metastasis via controlling AS of pre-mRNA. We propose that TRA2Ais a novel biomarker and therapeutic target for cancer progression and therapy. |
| first_indexed | 2024-04-09T15:17:38Z |
| format | Article |
| id | doaj.art-d9197b77a1d54c0d886512340f678480 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:17:38Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d9197b77a1d54c0d886512340f6784802023-04-29T14:57:00ZengElsevierHeliyon2405-84402023-04-0194e15516TRA2: The dominant power of alternative splicing in tumorsJiancheng Xue0Tie Ma1Xiaowen Zhang2Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Research and Application of Animal Model for Environmental and Metabolic Diseases, Shenyang, ChinaDepartment of Pathology, Shengjing Hospital of China Medical University, Shenyang, China; Corresponding author.Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Research and Application of Animal Model for Environmental and Metabolic Diseases, Shenyang, China; Corresponding author. Medical Research Center, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, Shenyang, 110004, China.The dysregulation of alternative splicing (AS) is frequently found in cancer and considered as key markers for cancer progression and therapy. Transformer 2 (TRA2), a nuclear RNA binding protein, consists of transformer 2 alpha homolog (TRA2A) and transformer 2 beta homolog (TRA2B), and plays a role in the regulation of pre-mRNA splicing. Growing evidence has been provided that TRA2A and TRA2B are dysregulated in several types of tumors, and participate in the regulation of proliferation, migration, invasion, and chemotherapy resistance in cancer cells through alteration of AS of cancer-related genes. In this review, we highlight the role of TRA2 in tumorigenesis and metastasis, and discuss potential molecular mechanisms how TRA2 influences tumorigenesis and metastasis via controlling AS of pre-mRNA. We propose that TRA2Ais a novel biomarker and therapeutic target for cancer progression and therapy.http://www.sciencedirect.com/science/article/pii/S2405844023027238Transformer 2Transformer 2 alpha homologTransformer 2 beta homologAlternative splicingTumorigenesis |
| spellingShingle | Jiancheng Xue Tie Ma Xiaowen Zhang TRA2: The dominant power of alternative splicing in tumors Heliyon Transformer 2 Transformer 2 alpha homolog Transformer 2 beta homolog Alternative splicing Tumorigenesis |
| title | TRA2: The dominant power of alternative splicing in tumors |
| title_full | TRA2: The dominant power of alternative splicing in tumors |
| title_fullStr | TRA2: The dominant power of alternative splicing in tumors |
| title_full_unstemmed | TRA2: The dominant power of alternative splicing in tumors |
| title_short | TRA2: The dominant power of alternative splicing in tumors |
| title_sort | tra2 the dominant power of alternative splicing in tumors |
| topic | Transformer 2 Transformer 2 alpha homolog Transformer 2 beta homolog Alternative splicing Tumorigenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023027238 |
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