Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis
ABSTRACTNowadays, drug-resistant tuberculosis (DR-TB) and co-infected tuberculosis (CI-TB) strains are the leading cause for the enhancement of long-term morbidity and unpredicted mortality rates from this ghoulish acid fast-bacterium infection, globally. Unfortunately, the lack of/ample lethargic t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1785334 |
| _version_ | 1797265902508441600 |
|---|---|
| author | Shasank S. Swain Divakar Sharma Tahziba Hussain Sanghamitra Pati |
| author_facet | Shasank S. Swain Divakar Sharma Tahziba Hussain Sanghamitra Pati |
| author_sort | Shasank S. Swain |
| collection | DOAJ |
| description | ABSTRACTNowadays, drug-resistant tuberculosis (DR-TB) and co-infected tuberculosis (CI-TB) strains are the leading cause for the enhancement of long-term morbidity and unpredicted mortality rates from this ghoulish acid fast-bacterium infection, globally. Unfortunately, the lack of/ample lethargic towards the development of compelling anti-TB regimens with a large-scale prevalence rate is a great challenge towards control of the pandemic situation. Indeed, the recent improvement in genomic studies for early diagnosis and understanding the mechanisms of drug resistance, as well as the identification of newer drug targets is quite remarkable and promising. Mainly, identification of such genetic factors, chromosomal mutations and associated pathways gives new ray of hope in current anti-TB drug discovery. This focused review provides molecular insights into the updated drug resistance mechanisms with encoded bacilli genetic factors as a novel target and potential source of development with screened-out newer anti-TB agents towards the control of MDR-TB soon. |
| first_indexed | 2024-03-07T17:24:32Z |
| format | Article |
| id | doaj.art-d91a71bc08cd458fa562a67dc4d03e37 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-25T00:52:10Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-d91a71bc08cd458fa562a67dc4d03e372024-03-11T16:04:23ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-01911651166310.1080/22221751.2020.1785334Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosisShasank S. Swain0Divakar Sharma1Tahziba Hussain2Sanghamitra Pati3Division of Microbiology and NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar, IndiaCRF, Mass Spectrometry Laboratory, Kusuma School of Biological Sciences (KSBS), Indian Institute of Technology-Delhi (IIT-D), Delhi, IndiaDivision of Microbiology and NCDs, ICMR-Regional Medical Research Centre, Bhubaneswar, IndiaDivision of Public Health and Research, ICMR-Regional Medical Research Centre, Bhubaneswar, IndiaABSTRACTNowadays, drug-resistant tuberculosis (DR-TB) and co-infected tuberculosis (CI-TB) strains are the leading cause for the enhancement of long-term morbidity and unpredicted mortality rates from this ghoulish acid fast-bacterium infection, globally. Unfortunately, the lack of/ample lethargic towards the development of compelling anti-TB regimens with a large-scale prevalence rate is a great challenge towards control of the pandemic situation. Indeed, the recent improvement in genomic studies for early diagnosis and understanding the mechanisms of drug resistance, as well as the identification of newer drug targets is quite remarkable and promising. Mainly, identification of such genetic factors, chromosomal mutations and associated pathways gives new ray of hope in current anti-TB drug discovery. This focused review provides molecular insights into the updated drug resistance mechanisms with encoded bacilli genetic factors as a novel target and potential source of development with screened-out newer anti-TB agents towards the control of MDR-TB soon.https://www.tandfonline.com/doi/10.1080/22221751.2020.1785334Multi-drug-resistant tuberculosisdrug resistance mechanismsanti-tubercular natural productsgenetic factorsmutations |
| spellingShingle | Shasank S. Swain Divakar Sharma Tahziba Hussain Sanghamitra Pati Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis Emerging Microbes and Infections Multi-drug-resistant tuberculosis drug resistance mechanisms anti-tubercular natural products genetic factors mutations |
| title | Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis |
| title_full | Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis |
| title_fullStr | Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis |
| title_full_unstemmed | Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis |
| title_short | Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis |
| title_sort | molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in mycobacterium tuberculosis |
| topic | Multi-drug-resistant tuberculosis drug resistance mechanisms anti-tubercular natural products genetic factors mutations |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1785334 |
| work_keys_str_mv | AT shasanksswain molecularmechanismsofunderlyinggeneticfactorsandassociatedmutationsfordrugresistanceinmycobacteriumtuberculosis AT divakarsharma molecularmechanismsofunderlyinggeneticfactorsandassociatedmutationsfordrugresistanceinmycobacteriumtuberculosis AT tahzibahussain molecularmechanismsofunderlyinggeneticfactorsandassociatedmutationsfordrugresistanceinmycobacteriumtuberculosis AT sanghamitrapati molecularmechanismsofunderlyinggeneticfactorsandassociatedmutationsfordrugresistanceinmycobacteriumtuberculosis |