Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones
This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of <i>p</i>-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a conven...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/6/2565 |
| _version_ | 1797609958791970816 |
|---|---|
| author | Caiyun Yang Sirou Hu Xinhui Pan Ke Yang Ke Zhang Qingguang Liu Xiaobing Xin Jie Li Jinhui Wang Xiaoda Yang |
| author_facet | Caiyun Yang Sirou Hu Xinhui Pan Ke Yang Ke Zhang Qingguang Liu Xiaobing Xin Jie Li Jinhui Wang Xiaoda Yang |
| author_sort | Caiyun Yang |
| collection | DOAJ |
| description | This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of <i>p</i>-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient synthetic method of 3-benzoylisoxazolines. |
| first_indexed | 2024-03-11T06:07:49Z |
| format | Article |
| id | doaj.art-d91ad62785bc488ba3dbc2d46d5c867b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T06:07:49Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d91ad62785bc488ba3dbc2d46d5c867b2023-11-17T12:52:05ZengMDPI AGMolecules1420-30492023-03-01286256510.3390/molecules28062565Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-NitroketonesCaiyun Yang0Sirou Hu1Xinhui Pan2Ke Yang3Ke Zhang4Qingguang Liu5Xiaobing Xin6Jie Li7Jinhui Wang8Xiaoda Yang9Key Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, ChinaThis article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of <i>p</i>-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient synthetic method of 3-benzoylisoxazolines.https://www.mdpi.com/1420-3049/28/6/2565α-nitroketonesalkenesalkynes1,3-dipolar cycloaddition<i>p</i>-TsOHisoxazolines |
| spellingShingle | Caiyun Yang Sirou Hu Xinhui Pan Ke Yang Ke Zhang Qingguang Liu Xiaobing Xin Jie Li Jinhui Wang Xiaoda Yang Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones Molecules α-nitroketones alkenes alkynes 1,3-dipolar cycloaddition <i>p</i>-TsOH isoxazolines |
| title | Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones |
| title_full | Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones |
| title_fullStr | Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones |
| title_full_unstemmed | Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones |
| title_short | Novel Synthesis of Dihydroisoxazoles by <i>p</i>-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones |
| title_sort | novel synthesis of dihydroisoxazoles by i p i tsoh participated 1 3 dipolar cycloaddition of dipolarophiles withα nitroketones |
| topic | α-nitroketones alkenes alkynes 1,3-dipolar cycloaddition <i>p</i>-TsOH isoxazolines |
| url | https://www.mdpi.com/1420-3049/28/6/2565 |
| work_keys_str_mv | AT caiyunyang novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT sirouhu novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT xinhuipan novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT keyang novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT kezhang novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT qingguangliu novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT xiaobingxin novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT jieli novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT jinhuiwang novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones AT xiaodayang novelsynthesisofdihydroisoxazolesbyipitsohparticipated13dipolarcycloadditionofdipolarophileswithanitroketones |