Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards

Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards

A series of N-mustards, which was conjugated to mono- or bis-naphthalimides with a flexible amine link, were synthesized and evaluated for cytotoxicity against five cancer cell lines (HCT-116, PC-3, U87 MG, Hep G2 and SK-OV-3). Several compounds displayed better activities than the control compound...

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Bibliographic Details
Main Authors:	Qinghua Lou, Liyan Ji, Wenhe Zhong, Shasha Li, Siwang Yu, Zhongjun Li, Xiangbao Meng
Format:	Article
Language:	English
Published:	MDPI AG 2014-06-01
Series:	Molecules
Subjects:	cytotoxicity DNA alkylating agent DNA intercalator synthesis N-mustard naphthalimide
Online Access:	http://www.mdpi.com/1420-3049/19/7/8803

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