Brain metastases of parathyroid carcinoma: Review of the literature and a case report
Background: Parathyroid carcinoma is a rare tumor typically presenting with marked elevations of serum calcium concentrations and associated renal and skeletal symptoms. Parathyroid carcinoma grows slowly, but may recur in regional lymph nodes, and, in about 25% of patients, metastasizes to the lung...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2015-09-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201503-0004_Brain_metastases_of_parathyroid_carcinoma_Review_of_the_literature_and_a_case_report.php |
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| author | Hana Studentova Bohuslav Melichar Jan Cincibuch Milan Kaminek Zdenek Frysak Marie Geierova Jiri Klein |
| author_facet | Hana Studentova Bohuslav Melichar Jan Cincibuch Milan Kaminek Zdenek Frysak Marie Geierova Jiri Klein |
| author_sort | Hana Studentova |
| collection | DOAJ |
| description | Background: Parathyroid carcinoma is a rare tumor typically presenting with marked elevations of serum calcium concentrations and associated renal and skeletal symptoms. Parathyroid carcinoma grows slowly, but may recur in regional lymph nodes, and, in about 25% of patients, metastasizes to the lungs.
Method: Description of a new case and review of the literature.
Results: We present here a patient with parathyroid carcinoma that had aggressive biological behavior with synchronous lung metastases and manifestation of brain metastases 18 month after the initial diagnosis and review earlier reports on this rare presentation. These metastases could be detected with [18F] fluorodeoxyglucose positron-emission tomography/computed tomography as well as with 99mtechnetium-sestamibi scan.
Conclusions: Except for surgery in case of isolated solitary metastases, therapeutic options in patients with brain metastases of parathyroid carcinoma are currently very limited. |
| first_indexed | 2024-12-13T03:15:20Z |
| format | Article |
| id | doaj.art-d923820c223749edb8ce3b74c69f8b90 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-13T03:15:20Z |
| publishDate | 2015-09-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-d923820c223749edb8ce3b74c69f8b902022-12-22T00:01:30ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212015-09-01159336036510.5507/bp.2015.001bio-201503-0004Brain metastases of parathyroid carcinoma: Review of the literature and a case reportHana Studentova0Bohuslav Melichar1Jan Cincibuch2Milan Kaminek3Zdenek Frysak4Marie Geierova5Jiri Klein6Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicDepartment of Nuclear Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital OlomoucDepartment of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital OlomoucDepartment of Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital OlomoucDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicBackground: Parathyroid carcinoma is a rare tumor typically presenting with marked elevations of serum calcium concentrations and associated renal and skeletal symptoms. Parathyroid carcinoma grows slowly, but may recur in regional lymph nodes, and, in about 25% of patients, metastasizes to the lungs. Method: Description of a new case and review of the literature. Results: We present here a patient with parathyroid carcinoma that had aggressive biological behavior with synchronous lung metastases and manifestation of brain metastases 18 month after the initial diagnosis and review earlier reports on this rare presentation. These metastases could be detected with [18F] fluorodeoxyglucose positron-emission tomography/computed tomography as well as with 99mtechnetium-sestamibi scan. Conclusions: Except for surgery in case of isolated solitary metastases, therapeutic options in patients with brain metastases of parathyroid carcinoma are currently very limited.https://biomed.papers.upol.cz/artkey/bio-201503-0004_Brain_metastases_of_parathyroid_carcinoma_Review_of_the_literature_and_a_case_report.phpparathyroid carcinomabrain metastaseshypercalcemia99mtechnetium-sestamibi |
| spellingShingle | Hana Studentova Bohuslav Melichar Jan Cincibuch Milan Kaminek Zdenek Frysak Marie Geierova Jiri Klein Brain metastases of parathyroid carcinoma: Review of the literature and a case report Biomedical Papers parathyroid carcinoma brain metastases hypercalcemia 99mtechnetium-sestamibi |
| title | Brain metastases of parathyroid carcinoma: Review of the literature and a case report |
| title_full | Brain metastases of parathyroid carcinoma: Review of the literature and a case report |
| title_fullStr | Brain metastases of parathyroid carcinoma: Review of the literature and a case report |
| title_full_unstemmed | Brain metastases of parathyroid carcinoma: Review of the literature and a case report |
| title_short | Brain metastases of parathyroid carcinoma: Review of the literature and a case report |
| title_sort | brain metastases of parathyroid carcinoma review of the literature and a case report |
| topic | parathyroid carcinoma brain metastases hypercalcemia 99mtechnetium-sestamibi |
| url | https://biomed.papers.upol.cz/artkey/bio-201503-0004_Brain_metastases_of_parathyroid_carcinoma_Review_of_the_literature_and_a_case_report.php |
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