Novel scientific approaches and future research directions in understanding ITP
Diagnosis of immune thrombocytopenia (ITP) and prediction of response to therapy remain significant and constant challenges in hematology. In patients who present with ITP, the platelet count is frequently used as a surrogate marker for disease severity, and so often determines the need for therapy....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-04-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1727871 |
| _version_ | 1797684230280445952 |
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| author | Sarah M. Hicks Lucy A. Coupland Anila Jahangiri Philip Y. Choi Elizabeth E. Gardiner |
| author_facet | Sarah M. Hicks Lucy A. Coupland Anila Jahangiri Philip Y. Choi Elizabeth E. Gardiner |
| author_sort | Sarah M. Hicks |
| collection | DOAJ |
| description | Diagnosis of immune thrombocytopenia (ITP) and prediction of response to therapy remain significant and constant challenges in hematology. In patients who present with ITP, the platelet count is frequently used as a surrogate marker for disease severity, and so often determines the need for therapy. Although there is a clear link between thrombocytopenia and hemostasis, a direct correlation between the extent of thrombocytopenia and bleeding symptoms, especially at lower platelet counts is lacking. Thus, bleeding in ITP is heterogeneous, unpredictable, and nearly always based on a multitude of risk factors, beyond the platelet count. The development of an evidence-based, validated risk stratification model for ITP treatment is a major goal in the ITP community and this review discusses new laboratory approaches to evaluate the various pathobiologies of ITP that may inform such a model. |
| first_indexed | 2024-03-12T00:26:39Z |
| format | Article |
| id | doaj.art-d924fb3f542846a5b5a182d3ebed21e9 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:39Z |
| publishDate | 2020-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-d924fb3f542846a5b5a182d3ebed21e92023-09-15T10:38:07ZengTaylor & Francis GroupPlatelets0953-71041369-16352020-04-0131331532110.1080/09537104.2020.17278711727871Novel scientific approaches and future research directions in understanding ITPSarah M. Hicks0Lucy A. Coupland1Anila Jahangiri2Philip Y. Choi3Elizabeth E. Gardiner4The John Curtin School of Medical Research, The Australian National UniversityThe John Curtin School of Medical Research, The Australian National UniversityThe John Curtin School of Medical Research, The Australian National UniversityThe John Curtin School of Medical Research, The Australian National UniversityThe John Curtin School of Medical Research, The Australian National UniversityDiagnosis of immune thrombocytopenia (ITP) and prediction of response to therapy remain significant and constant challenges in hematology. In patients who present with ITP, the platelet count is frequently used as a surrogate marker for disease severity, and so often determines the need for therapy. Although there is a clear link between thrombocytopenia and hemostasis, a direct correlation between the extent of thrombocytopenia and bleeding symptoms, especially at lower platelet counts is lacking. Thus, bleeding in ITP is heterogeneous, unpredictable, and nearly always based on a multitude of risk factors, beyond the platelet count. The development of an evidence-based, validated risk stratification model for ITP treatment is a major goal in the ITP community and this review discusses new laboratory approaches to evaluate the various pathobiologies of ITP that may inform such a model.http://dx.doi.org/10.1080/09537104.2020.1727871autoantibodyitpplateletreceptorthrombocytopenia |
| spellingShingle | Sarah M. Hicks Lucy A. Coupland Anila Jahangiri Philip Y. Choi Elizabeth E. Gardiner Novel scientific approaches and future research directions in understanding ITP Platelets autoantibody itp platelet receptor thrombocytopenia |
| title | Novel scientific approaches and future research directions in understanding ITP |
| title_full | Novel scientific approaches and future research directions in understanding ITP |
| title_fullStr | Novel scientific approaches and future research directions in understanding ITP |
| title_full_unstemmed | Novel scientific approaches and future research directions in understanding ITP |
| title_short | Novel scientific approaches and future research directions in understanding ITP |
| title_sort | novel scientific approaches and future research directions in understanding itp |
| topic | autoantibody itp platelet receptor thrombocytopenia |
| url | http://dx.doi.org/10.1080/09537104.2020.1727871 |
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