[<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma
Hodgkin’s lymphoma (HL) is one of the neoplasms with the best prognosis in children, adolescents and young adults, but sufferers are burdened by the possibility of developing adverse effects such as Bone Ischemic Lesions (BILs) which are lesions of the bone caused by the loss of/reduction in blood f...
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/3/565 |
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| author | Chiara Giraudo Elisa Carraro Elena Cavallaro Monica Zuliani Liliya Spampinato Gotsyak Davide Massano Antonella Modugno Lara Mussolin Alessandra Biffi Diego Cecchin Marta Pillon Pietro Zucchetta |
| author_facet | Chiara Giraudo Elisa Carraro Elena Cavallaro Monica Zuliani Liliya Spampinato Gotsyak Davide Massano Antonella Modugno Lara Mussolin Alessandra Biffi Diego Cecchin Marta Pillon Pietro Zucchetta |
| author_sort | Chiara Giraudo |
| collection | DOAJ |
| description | Hodgkin’s lymphoma (HL) is one of the neoplasms with the best prognosis in children, adolescents and young adults, but sufferers are burdened by the possibility of developing adverse effects such as Bone Ischemic Lesions (BILs) which are lesions of the bone caused by the loss of/reduction in blood flow. The main goal of this retrospective study was to evaluate the role of [<sup>18</sup>F]FDG-PET-MR in the early detection of BILs in a single-center cohort of uniformly treated pediatric HL patients. BILs were assessed through PET-MR images as the appearance of medullary lesion surrounded by a serpiginous, tortuous border. From 2017 to 2022, 10/53 (18.9%) HL patients developed BILs which were mostly (8/10 patients) multifocal. Overall, 30 lesions were identified in the 10 asymptomatic patients, all with the above-mentioned features at MR and with very low [<sup>18</sup>F]FDG uptake. BILs were incidentally detected during HL therapy (<i>n</i> = 6) and follow-up (<i>n</i> = 4), especially in the long bones (66.7%). No factors correlated with the occurrence of BIL were identified. No patients developed complications. PET-MR is a sensitive combined-imaging technique for detecting BILs that are asymptomatic and self-limiting micro-ischemic lesions. BILs can be monitored by clinical follow-up alone both during and after therapy. |
| first_indexed | 2024-03-11T09:48:31Z |
| format | Article |
| id | doaj.art-d9254927d6f34050b124cc477a839693 |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T09:48:31Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d9254927d6f34050b124cc477a8396932023-11-16T16:26:43ZengMDPI AGDiagnostics2075-44182023-02-0113356510.3390/diagnostics13030565[<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s LymphomaChiara Giraudo0Elisa Carraro1Elena Cavallaro2Monica Zuliani3Liliya Spampinato Gotsyak4Davide Massano5Antonella Modugno6Lara Mussolin7Alessandra Biffi8Diego Cecchin9Marta Pillon10Pietro Zucchetta11Department of Medicine-DIMED, Nuclear Medicine Unit, Padova University Hospital, 35128 Padova, ItalyPediatric Hematology, Oncology and Stem Cell Transplant Division, Padova University Hospital, 35128 Padova, ItalyMaternal and Child Health Department, Padova University, 35128 Padova, ItalyDepartment of Medicine, Pediatric Radiology Unit-Neuroradiology Institute Hospital, University of Padova, 35128 Padova, ItalyMaternal and Child Health Department, Padova University, 35128 Padova, ItalyPediatric Hematology, Oncology and Stem Cell Transplant Division, Padova University Hospital, 35128 Padova, ItalyRadiology Unit, Hospital of Camposampiero, 35012 Camposampiero, ItalyMaternal and Child Health Department, Padova University, 35128 Padova, ItalyPediatric Hematology, Oncology and Stem Cell Transplant Division, Padova University Hospital, 35128 Padova, ItalyDepartment of Medicine-DIMED, Nuclear Medicine Unit, School of Medicine, University Hospital of Padova, 35128 Padova, ItalyPediatric Hematology, Oncology and Stem Cell Transplant Division, Padova University Hospital, 35128 Padova, ItalyDepartment of Medicine-DIMED, Nuclear Medicine Unit, School of Medicine, University Hospital of Padova, 35128 Padova, ItalyHodgkin’s lymphoma (HL) is one of the neoplasms with the best prognosis in children, adolescents and young adults, but sufferers are burdened by the possibility of developing adverse effects such as Bone Ischemic Lesions (BILs) which are lesions of the bone caused by the loss of/reduction in blood flow. The main goal of this retrospective study was to evaluate the role of [<sup>18</sup>F]FDG-PET-MR in the early detection of BILs in a single-center cohort of uniformly treated pediatric HL patients. BILs were assessed through PET-MR images as the appearance of medullary lesion surrounded by a serpiginous, tortuous border. From 2017 to 2022, 10/53 (18.9%) HL patients developed BILs which were mostly (8/10 patients) multifocal. Overall, 30 lesions were identified in the 10 asymptomatic patients, all with the above-mentioned features at MR and with very low [<sup>18</sup>F]FDG uptake. BILs were incidentally detected during HL therapy (<i>n</i> = 6) and follow-up (<i>n</i> = 4), especially in the long bones (66.7%). No factors correlated with the occurrence of BIL were identified. No patients developed complications. PET-MR is a sensitive combined-imaging technique for detecting BILs that are asymptomatic and self-limiting micro-ischemic lesions. BILs can be monitored by clinical follow-up alone both during and after therapy.https://www.mdpi.com/2075-4418/13/3/565bone ischemic lesionchildhoodadolescentPET-MRHodgkin’s lymphoma |
| spellingShingle | Chiara Giraudo Elisa Carraro Elena Cavallaro Monica Zuliani Liliya Spampinato Gotsyak Davide Massano Antonella Modugno Lara Mussolin Alessandra Biffi Diego Cecchin Marta Pillon Pietro Zucchetta [<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma Diagnostics bone ischemic lesion childhood adolescent PET-MR Hodgkin’s lymphoma |
| title | [<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma |
| title_full | [<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma |
| title_fullStr | [<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma |
| title_full_unstemmed | [<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma |
| title_short | [<sup>18</sup>F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma |
| title_sort | sup 18 sup f fdg pet mr in the evaluation and follow up of incidental bone ischemic lesions in a mono center cohort of pediatric patients affected by hodgkin s lymphoma |
| topic | bone ischemic lesion childhood adolescent PET-MR Hodgkin’s lymphoma |
| url | https://www.mdpi.com/2075-4418/13/3/565 |
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