Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor

Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor

In the current study, we demonstrate that integrin α3β1 promotes invasive and metastatic traits of triple-negative breast cancer (TNBC) cells through induction of the transcription factor, Brain-2 (Brn-2). We show that RNAi-mediated suppression of α3β1 in MDA-MB-231 cells caused reduced expression o...

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Bibliographic Details
Main Authors: Rakshitha Pandulal Miskin, Janine S. A. Warren, Abibatou Ndoye, Lei Wu, John M. Lamar, C. Michael DiPersio
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
triple-negative breast cancer
integrin α3β1
tumor cell invasion
metastasis
Brain-2
Brn-2
Online Access:https://www.mdpi.com/2072-6694/13/3/480

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