Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma
Objectives To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs). Methods This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The samp...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2022-03-01
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| Series: | Journal of Coloproctology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1739299 |
| _version_ | 1819280436497481728 |
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| author | Thiago da Silveira Manzione Sidney Roberto Nadal Antônio José Gonçalves |
| author_facet | Thiago da Silveira Manzione Sidney Roberto Nadal Antônio José Gonçalves |
| author_sort | Thiago da Silveira Manzione |
| collection | DOAJ |
| description | Objectives To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs).
Methods This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The sample comprised 54 patients presenting acetowhite lesions on anal colposcopy. Acetowhite lesions were classified according to their morphology into punctation, verrucous, mosaic, ulcerated, or hypervascularized, and biopsies of these specimens were classified as anal HSIL, low-grade squamous intraepithelial lesion (LSIL), or normal. The data were analyzed using SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The results were analyzed using the nonparametric Mann-Whitney test, the Fisher exact test and the chi-squared parametric test. A 95% confidence interval (CI) was used and a level of significance < 5% was adopted for all statistical tests.
Results Fifty-four patients (50 males, 80% HIV + ) with biopsied acetowhite lesions were assessed. There were 31 punctation lesions, 1 classified as HSIL (3.2%; 95%CI: 0–40.0), 17 verrucous lesions, 3 HSIL (17.7%; 95%CI: 0–10.7), and 1 ulcerated, classified as HSIL (100%), and 4 mosaic and 1 atypical vessel lesion, all classified as LSIL. The results showed no association of presence of anal HSIL with positivity for HIV infection or with counts above or below 500/µl in HIV+ patients. Statistical analysis was performed using the Mann-Whitney nonparametric test, the Fisher exact test, and the chi-squared parametric test.
Conclusion The comparison of morphological findings on anal colposcopy against histology revealed no morphological pattern suggesting anal HSIL. |
| first_indexed | 2024-12-24T00:43:46Z |
| format | Article |
| id | doaj.art-d9260a8f7d654c08a74d80c6ca0490a7 |
| institution | Directory Open Access Journal |
| issn | 2237-9363 2317-6423 |
| language | English |
| last_indexed | 2024-12-24T00:43:46Z |
| publishDate | 2022-03-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Journal of Coloproctology |
| spelling | doaj.art-d9260a8f7d654c08a74d80c6ca0490a72022-12-21T17:23:53ZengThieme Revinter Publicações Ltda.Journal of Coloproctology2237-93632317-64232022-03-01420106306710.1055/s-0041-1739299Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal CondylomaThiago da Silveira Manzione0Sidney Roberto Nadal1Antônio José Gonçalves2Surgery Department, Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, SP, BrazilInstituto de Infectologia Emilio Ribas, São Paulo, SP, BrazilFaculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, BrazilObjectives To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs). Methods This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The sample comprised 54 patients presenting acetowhite lesions on anal colposcopy. Acetowhite lesions were classified according to their morphology into punctation, verrucous, mosaic, ulcerated, or hypervascularized, and biopsies of these specimens were classified as anal HSIL, low-grade squamous intraepithelial lesion (LSIL), or normal. The data were analyzed using SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The results were analyzed using the nonparametric Mann-Whitney test, the Fisher exact test and the chi-squared parametric test. A 95% confidence interval (CI) was used and a level of significance < 5% was adopted for all statistical tests. Results Fifty-four patients (50 males, 80% HIV + ) with biopsied acetowhite lesions were assessed. There were 31 punctation lesions, 1 classified as HSIL (3.2%; 95%CI: 0–40.0), 17 verrucous lesions, 3 HSIL (17.7%; 95%CI: 0–10.7), and 1 ulcerated, classified as HSIL (100%), and 4 mosaic and 1 atypical vessel lesion, all classified as LSIL. The results showed no association of presence of anal HSIL with positivity for HIV infection or with counts above or below 500/µl in HIV+ patients. Statistical analysis was performed using the Mann-Whitney nonparametric test, the Fisher exact test, and the chi-squared parametric test. Conclusion The comparison of morphological findings on anal colposcopy against histology revealed no morphological pattern suggesting anal HSIL.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1739299anal colposcopyhigh-resolution anoscopyanal high-grade squamous intraepithelial lesionanal condyloma |
| spellingShingle | Thiago da Silveira Manzione Sidney Roberto Nadal Antônio José Gonçalves Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma Journal of Coloproctology anal colposcopy high-resolution anoscopy anal high-grade squamous intraepithelial lesion anal condyloma |
| title | Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma |
| title_full | Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma |
| title_fullStr | Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma |
| title_full_unstemmed | Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma |
| title_short | Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma |
| title_sort | comparative analysis of anal colposcopy with histology in the follow up of patients under treatment for anal condyloma |
| topic | anal colposcopy high-resolution anoscopy anal high-grade squamous intraepithelial lesion anal condyloma |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1739299 |
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