Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques
Although research on the treatment of atherosclerosis has progressed recently, challenges remain in developing more effective, safer and transformative strategies for the treatment of atherosclerosis. Nanomaterials have recently played a unique role in many fields, including atherosclerosis treatmen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.868063/full |
| _version_ | 1819121707333451776 |
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| author | Jia Zhou Jia Zhou Chengcheng Niu Biying Huang Sijie Chen Caigui Yu Sheng Cao Wenjing Pei Ruiqiang Guo |
| author_facet | Jia Zhou Jia Zhou Chengcheng Niu Biying Huang Sijie Chen Caigui Yu Sheng Cao Wenjing Pei Ruiqiang Guo |
| author_sort | Jia Zhou |
| collection | DOAJ |
| description | Although research on the treatment of atherosclerosis has progressed recently, challenges remain in developing more effective, safer and transformative strategies for the treatment of atherosclerosis. Nanomaterials have recently played a unique role in many fields, including atherosclerosis treatment. Platelets are common component in the blood. Due to their inherent properties, platelets can target and adhere to atherosclerotic plaques. Ultrasound-targeted microbubble destruction (UTMD) shows great prospects in promoting the efficiency of drug delivery in treating solid tumors. In this study, we explored the possibility that UTMD assists platelet biomimetic rapamycin (RAP)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (RAP@PLT NPs) in the treatment of atherosclerosis. The biomimetic nano-formulations exhibit better targeting ability to plaques when administered in vivo. Targeted destruction of Sonovue™ in the aortic area further improved the efficiency of targeting plaques. Moreover, the progression of atherosclerotic plaques was inhibited, and the stability of plaques was improved. Together, our study established a novel strategy for targeted delivery of nanoparticles in atherosclerotic plaques, by combining the advantages of the ultrasonic cavitation effect and biomimicking nanoparticles in drug delivery. |
| first_indexed | 2024-12-22T06:40:50Z |
| format | Article |
| id | doaj.art-d92bd044967c43c9bdfb5d1c1b9f6fc0 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-22T06:40:50Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-d92bd044967c43c9bdfb5d1c1b9f6fc02022-12-21T18:35:27ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-03-011010.3389/fchem.2022.868063868063Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic PlaquesJia Zhou0Jia Zhou1Chengcheng Niu2Biying Huang3Sijie Chen4Caigui Yu5Sheng Cao6Wenjing Pei7Ruiqiang Guo8Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Ultrasound Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, ChinaAlthough research on the treatment of atherosclerosis has progressed recently, challenges remain in developing more effective, safer and transformative strategies for the treatment of atherosclerosis. Nanomaterials have recently played a unique role in many fields, including atherosclerosis treatment. Platelets are common component in the blood. Due to their inherent properties, platelets can target and adhere to atherosclerotic plaques. Ultrasound-targeted microbubble destruction (UTMD) shows great prospects in promoting the efficiency of drug delivery in treating solid tumors. In this study, we explored the possibility that UTMD assists platelet biomimetic rapamycin (RAP)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (RAP@PLT NPs) in the treatment of atherosclerosis. The biomimetic nano-formulations exhibit better targeting ability to plaques when administered in vivo. Targeted destruction of Sonovue™ in the aortic area further improved the efficiency of targeting plaques. Moreover, the progression of atherosclerotic plaques was inhibited, and the stability of plaques was improved. Together, our study established a novel strategy for targeted delivery of nanoparticles in atherosclerotic plaques, by combining the advantages of the ultrasonic cavitation effect and biomimicking nanoparticles in drug delivery.https://www.frontiersin.org/articles/10.3389/fchem.2022.868063/fullultrasound-targeted microbubble destruction (UTMD)rapamycin (RAP)biomimicking nanoparticlesatherosclerotic plaquesplatelet membrane coating |
| spellingShingle | Jia Zhou Jia Zhou Chengcheng Niu Biying Huang Sijie Chen Caigui Yu Sheng Cao Wenjing Pei Ruiqiang Guo Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques Frontiers in Chemistry ultrasound-targeted microbubble destruction (UTMD) rapamycin (RAP) biomimicking nanoparticles atherosclerotic plaques platelet membrane coating |
| title | Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques |
| title_full | Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques |
| title_fullStr | Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques |
| title_full_unstemmed | Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques |
| title_short | Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques |
| title_sort | platelet membrane biomimetic nanoparticles combined with utmd to improve the stability of atherosclerotic plaques |
| topic | ultrasound-targeted microbubble destruction (UTMD) rapamycin (RAP) biomimicking nanoparticles atherosclerotic plaques platelet membrane coating |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.868063/full |
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