Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis
Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly...
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8131 |
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| author | Deepika Watts Diana Gaete Diego Rodriguez David Hoogewijs Martina Rauner Sundary Sormendi Ben Wielockx |
| author_facet | Deepika Watts Diana Gaete Diego Rodriguez David Hoogewijs Martina Rauner Sundary Sormendi Ben Wielockx |
| author_sort | Deepika Watts |
| collection | DOAJ |
| description | Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO<sub>2</sub>) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO. However, erythropoiesis regulation extends beyond the well-established hypoxia-inducible factor (HIF)–EPO axis and involves processes modulated by other hypoxia pathway proteins (HPPs), including proteins involved in iron metabolism. The importance of a number of these factors is evident as their altered expression has been associated with various anemia-related disorders, including chronic kidney disease. Eventually, our emerging understanding of HPPs and their regulatory feedback will be instrumental in developing specific therapies for anemic patients and beyond. |
| first_indexed | 2024-03-10T15:12:24Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:12:24Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d92d559385ff440fbc1f5f4fcd65b4532023-11-20T19:14:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121813110.3390/ijms21218131Hypoxia Pathway Proteins are Master Regulators of ErythropoiesisDeepika Watts0Diana Gaete1Diego Rodriguez2David Hoogewijs3Martina Rauner4Sundary Sormendi5Ben Wielockx6Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, GermanySection of Medicine, Department of Endocrinology, Metabolism and Cardiovascular System, University of Fribourg, 1700 Fribourg, SwitzerlandDepartment of Medicine III and Center for Healthy Aging, Technische Universität Dresden, 01307 Dresden, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, GermanyErythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO<sub>2</sub>) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO. However, erythropoiesis regulation extends beyond the well-established hypoxia-inducible factor (HIF)–EPO axis and involves processes modulated by other hypoxia pathway proteins (HPPs), including proteins involved in iron metabolism. The importance of a number of these factors is evident as their altered expression has been associated with various anemia-related disorders, including chronic kidney disease. Eventually, our emerging understanding of HPPs and their regulatory feedback will be instrumental in developing specific therapies for anemic patients and beyond.https://www.mdpi.com/1422-0067/21/21/8131hypoxiaerythropoiesisEPOHIFCKD |
| spellingShingle | Deepika Watts Diana Gaete Diego Rodriguez David Hoogewijs Martina Rauner Sundary Sormendi Ben Wielockx Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis International Journal of Molecular Sciences hypoxia erythropoiesis EPO HIF CKD |
| title | Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis |
| title_full | Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis |
| title_fullStr | Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis |
| title_full_unstemmed | Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis |
| title_short | Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis |
| title_sort | hypoxia pathway proteins are master regulators of erythropoiesis |
| topic | hypoxia erythropoiesis EPO HIF CKD |
| url | https://www.mdpi.com/1422-0067/21/21/8131 |
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