Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production

Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production

The obligate anaerobe, spore forming bacterium Clostridioides difficile (formerly Clostridium difficile) causes nosocomial and community acquired diarrhea often associated with antibiotic therapy. Major virulence factors of the bacterium are the two large clostridial toxins TcdA and TcdB. The produc...

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Bibliographic Details
Main Authors: Julia D. Hofmann, Andreas Otto, Mareike Berges, Rebekka Biedendieck, Annika-Marisa Michel, Dörte Becher, Dieter Jahn, Meina Neumann-Schaal
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
Clostridium difficile
Clostridioides difficile
metabolism
toxin formation
starvation
Stickland reactions
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01970/full

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