Conditional deletion of CD98hc inhibits osteoclast development

Conditional deletion of CD98hc inhibits osteoclast development

The CD98 heavy chain (CD98hc) regulates virus-induced cell fusion and monocyte fusion, and is involved in amino acid transportation. Here, we examined the role that CD98hc plays in the formation of osteoclasts using CD98hcflox/floxLysM-cre peritoneal macrophages (CD98hc-defect macrophages). Peritone...

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Bibliographic Details
Main Authors: Hideki Tsumura, Morihiro Ito, Masamichi Takami, Miyuki Arai, Xiao-Kang Li, Toshio Hamatani, Arisa Igarashi, Shuji Takada, Kenji Miyado, Akihiro Umezawa, Yasuhiko Ito
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
CD98 heavy chain
Osteoclast formation
RANKL
Integrin signaling
Amino acid transport
Amino acid starvation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580815001430

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