Natural Killer Cells Exhibit a Peculiar Phenotypic Profile in Systemic Sclerosis and Are Potent Inducers of Endothelial Microparticles Release

Natural Killer Cells Exhibit a Peculiar Phenotypic Profile in Systemic Sclerosis and Are Potent Inducers of Endothelial Microparticles Release

The pathophysiology of systemic sclerosis (SSc) involves early endothelial and immune activation, both preceding the onset of fibrosis. We previously identified soluble fractalkine and circulating endothelial microparticles (EMPs) as biomarkers of endothelial inflammatory activation in SSc. Fractalk...

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Bibliographic Details
Main Authors: Audrey Benyamine, Jérémy Magalon, Florence Sabatier, Luc Lyonnet, Stéphane Robert, Chloé Dumoulin, Sophie Morange, Karin Mazodier, Gilles Kaplanski, Martine Reynaud-Gaubert, Pascal Rossi, Françoise Dignat-George, Brigitte Granel, Pascale Paul
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
endothelial microparticles
fractalkine
CX3CR1
systemic sclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01665/full

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