Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells
The energetically costly mammalian investment in gestation and lactation requires plentiful nutritional sources and thus links the environmental conditions to reproductive success. Flexibility in adjusting developmental timing enhances chances of survival in adverse conditions. Over 130 mammalian sp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.708318/full |
| _version_ | 1818655787892867072 |
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| author | Vera A. van der Weijden Aydan Bulut-Karslioglu |
| author_facet | Vera A. van der Weijden Aydan Bulut-Karslioglu |
| author_sort | Vera A. van der Weijden |
| collection | DOAJ |
| description | The energetically costly mammalian investment in gestation and lactation requires plentiful nutritional sources and thus links the environmental conditions to reproductive success. Flexibility in adjusting developmental timing enhances chances of survival in adverse conditions. Over 130 mammalian species can reversibly pause early embryonic development by switching to a near dormant state that can be sustained for months, a phenomenon called embryonic diapause. Lineage-specific cells are retained during diapause, and they proliferate and differentiate upon activation. Studying diapause thus reveals principles of pluripotency and dormancy and is not only relevant for development, but also for regeneration and cancer. In this review, we focus on the molecular regulation of diapause in early mammalian embryos and relate it to maintenance of potency in stem cells in vitro. Diapause is established and maintained by active rewiring of the embryonic metabolome, epigenome, and gene expression in communication with maternal tissues. Herein, we particularly discuss factors required at distinct stages of diapause to induce, maintain, and terminate dormancy. |
| first_indexed | 2024-12-17T03:15:15Z |
| format | Article |
| id | doaj.art-d92fc07562324c27831d0deb4fa2ac70 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T03:15:15Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d92fc07562324c27831d0deb4fa2ac702022-12-21T22:05:42ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.708318708318Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem CellsVera A. van der WeijdenAydan Bulut-KarsliogluThe energetically costly mammalian investment in gestation and lactation requires plentiful nutritional sources and thus links the environmental conditions to reproductive success. Flexibility in adjusting developmental timing enhances chances of survival in adverse conditions. Over 130 mammalian species can reversibly pause early embryonic development by switching to a near dormant state that can be sustained for months, a phenomenon called embryonic diapause. Lineage-specific cells are retained during diapause, and they proliferate and differentiate upon activation. Studying diapause thus reveals principles of pluripotency and dormancy and is not only relevant for development, but also for regeneration and cancer. In this review, we focus on the molecular regulation of diapause in early mammalian embryos and relate it to maintenance of potency in stem cells in vitro. Diapause is established and maintained by active rewiring of the embryonic metabolome, epigenome, and gene expression in communication with maternal tissues. Herein, we particularly discuss factors required at distinct stages of diapause to induce, maintain, and terminate dormancy.https://www.frontiersin.org/articles/10.3389/fcell.2021.708318/fullembryonic diapausepluripotencydormancymetabolismtranscriptionmiRNA |
| spellingShingle | Vera A. van der Weijden Aydan Bulut-Karslioglu Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells Frontiers in Cell and Developmental Biology embryonic diapause pluripotency dormancy metabolism transcription miRNA |
| title | Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells |
| title_full | Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells |
| title_fullStr | Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells |
| title_full_unstemmed | Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells |
| title_short | Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells |
| title_sort | molecular regulation of paused pluripotency in early mammalian embryos and stem cells |
| topic | embryonic diapause pluripotency dormancy metabolism transcription miRNA |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.708318/full |
| work_keys_str_mv | AT veraavanderweijden molecularregulationofpausedpluripotencyinearlymammalianembryosandstemcells AT aydanbulutkarslioglu molecularregulationofpausedpluripotencyinearlymammalianembryosandstemcells |