rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman
Introduction: Inflammatory myofibroblastic tumours are rare neoplasms which most commonly affect children and young adults. With an intermediate malignant potential, they are typically detected in the abdomen, lung, mediastinum, head and neck, gastrointestinal tract, and genitourinary tract. Case...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2023-04-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/3626 |
| _version_ | 1797851134847614976 |
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| author | Jojo Yorke Krupa Solanki Vaishnavi Theegala Alok Sinha Don Asberry Adel El Abbassi |
| author_facet | Jojo Yorke Krupa Solanki Vaishnavi Theegala Alok Sinha Don Asberry Adel El Abbassi |
| author_sort | Jojo Yorke |
| collection | DOAJ |
| description | Introduction: Inflammatory myofibroblastic tumours are rare neoplasms which most commonly affect children and young adults. With an intermediate malignant potential, they are typically detected in the abdomen, lung, mediastinum, head and neck, gastrointestinal tract, and genitourinary tract.
Case description: We describe the case of a 33-year-old postpartum woman incidentally diagnosed with a pulmonary inflammatory myofibroblastic tumour following complaints of poorly controlled hypertension a week after caesarean section. She was ALK-negative and received an ALK inhibitor with complete resolution of the lesion. A ROS1–TFG fusion confirmed the diagnosis of an inflammatory myofibroblastic tumour after CT-guided fine needle aspiration.
Discussion: This case highlights an uncommon presentation posing a diagnostic and therapeutic challenge and the potential treatment option of crizotinib. |
| first_indexed | 2024-04-09T19:12:56Z |
| format | Article |
| id | doaj.art-d930ab363f564d779abbb9036751cabc |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-04-09T19:12:56Z |
| publishDate | 2023-04-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-d930ab363f564d779abbb9036751cabc2023-04-06T14:29:51ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942023-04-0110.12890/2023_0036263161rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum womanJojo Yorke0Krupa Solanki1Vaishnavi Theegala2Alok Sinha3Don Asberry4Adel El Abbassi5Department of Internal Medicine, Division of Pulmonary/Critical Care, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, USADepartment of Internal Medicine, Division of Pulmonary/Critical Care, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, USADepartment of Internal Medicine, Division of Pulmonary/Critical Care, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, USADepartment of Pathology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, USADepartment of Pathology, Highlands Pathology, Bristol, USABristol Regional Medical Center, Bristol, USAIntroduction: Inflammatory myofibroblastic tumours are rare neoplasms which most commonly affect children and young adults. With an intermediate malignant potential, they are typically detected in the abdomen, lung, mediastinum, head and neck, gastrointestinal tract, and genitourinary tract. Case description: We describe the case of a 33-year-old postpartum woman incidentally diagnosed with a pulmonary inflammatory myofibroblastic tumour following complaints of poorly controlled hypertension a week after caesarean section. She was ALK-negative and received an ALK inhibitor with complete resolution of the lesion. A ROS1–TFG fusion confirmed the diagnosis of an inflammatory myofibroblastic tumour after CT-guided fine needle aspiration. Discussion: This case highlights an uncommon presentation posing a diagnostic and therapeutic challenge and the potential treatment option of crizotinib.https://www.ejcrim.com/index.php/EJCRIM/article/view/3626pulmonary inflammatory myofibroblastic tumorhypertension |
| spellingShingle | Jojo Yorke Krupa Solanki Vaishnavi Theegala Alok Sinha Don Asberry Adel El Abbassi rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman European Journal of Case Reports in Internal Medicine pulmonary inflammatory myofibroblastic tumor hypertension |
| title | rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman |
| title_full | rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman |
| title_fullStr | rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman |
| title_full_unstemmed | rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman |
| title_short | rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman |
| title_sort | rare case of incidentally diagnosed pulmonary inflammatory myofibroblastic tumour with dramatic response to crizotinib in a postpartum woman |
| topic | pulmonary inflammatory myofibroblastic tumor hypertension |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/3626 |
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