The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration
Peripheral nerves are frequently affected by lesions caused by trauma (work accidents, car incidents, combat injuries) and following surgical procedures (for instance cancer resection), resulting in loss of motor and sensory function with lifelong impairments. Irrespective of the intrinsic capabilit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5177 |
| _version_ | 1797504375923408896 |
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| author | Luisa Muratori Federica Fregnan Monica Maurina Kirsten Haastert-Talini Giulia Ronchi |
| author_facet | Luisa Muratori Federica Fregnan Monica Maurina Kirsten Haastert-Talini Giulia Ronchi |
| author_sort | Luisa Muratori |
| collection | DOAJ |
| description | Peripheral nerves are frequently affected by lesions caused by trauma (work accidents, car incidents, combat injuries) and following surgical procedures (for instance cancer resection), resulting in loss of motor and sensory function with lifelong impairments. Irrespective of the intrinsic capability of the peripheral nervous system for regeneration, spontaneous or surgically supported regeneration is often unsatisfactory with the limited functional success of nerve repair. For this reason, many efforts have been made to improve the regeneration process. Beyond innovative microsurgical methods that, in certain cases, are necessary to repair nerve injuries, different nonsurgical treatment approaches and adjunctive therapies have been investigated to enhance nerve regeneration. One possibility could be taking advantage of a healthy diet or lifestyle and their relation with proper body functions. Over the years, scientific evidence has been obtained on the benefits of the intake of polyphenols or polyphenol-rich foods in humans, highlighting the neuroprotective effects of these compounds in many neurodegenerative diseases. In order to improve the available knowledge about the potential beneficial role of polyphenols in the process of peripheral nerve regeneration, this review assessed the biological effects of polyphenol administration in supporting and promoting the regenerative process after peripheral nerve injury. |
| first_indexed | 2024-03-10T04:03:44Z |
| format | Article |
| id | doaj.art-d934c65cb26e40fb8d083916828bb773 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:03:44Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d934c65cb26e40fb8d083916828bb7732023-11-23T08:28:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239517710.3390/ijms23095177The Potential Benefits of Dietary Polyphenols for Peripheral Nerve RegenerationLuisa Muratori0Federica Fregnan1Monica Maurina2Kirsten Haastert-Talini3Giulia Ronchi4Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, (Torino), ItalyDepartment of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, (Torino), ItalyDepartment of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, (Torino), ItalyInstitute of Neuroanatomy and Cell Biology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, (Torino), ItalyPeripheral nerves are frequently affected by lesions caused by trauma (work accidents, car incidents, combat injuries) and following surgical procedures (for instance cancer resection), resulting in loss of motor and sensory function with lifelong impairments. Irrespective of the intrinsic capability of the peripheral nervous system for regeneration, spontaneous or surgically supported regeneration is often unsatisfactory with the limited functional success of nerve repair. For this reason, many efforts have been made to improve the regeneration process. Beyond innovative microsurgical methods that, in certain cases, are necessary to repair nerve injuries, different nonsurgical treatment approaches and adjunctive therapies have been investigated to enhance nerve regeneration. One possibility could be taking advantage of a healthy diet or lifestyle and their relation with proper body functions. Over the years, scientific evidence has been obtained on the benefits of the intake of polyphenols or polyphenol-rich foods in humans, highlighting the neuroprotective effects of these compounds in many neurodegenerative diseases. In order to improve the available knowledge about the potential beneficial role of polyphenols in the process of peripheral nerve regeneration, this review assessed the biological effects of polyphenol administration in supporting and promoting the regenerative process after peripheral nerve injury.https://www.mdpi.com/1422-0067/23/9/5177nerve injuriesdietfoodflavonoidnon-flavonoid |
| spellingShingle | Luisa Muratori Federica Fregnan Monica Maurina Kirsten Haastert-Talini Giulia Ronchi The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration International Journal of Molecular Sciences nerve injuries diet food flavonoid non-flavonoid |
| title | The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration |
| title_full | The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration |
| title_fullStr | The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration |
| title_full_unstemmed | The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration |
| title_short | The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration |
| title_sort | potential benefits of dietary polyphenols for peripheral nerve regeneration |
| topic | nerve injuries diet food flavonoid non-flavonoid |
| url | https://www.mdpi.com/1422-0067/23/9/5177 |
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