Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy

Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy

Abstract Background Hypoxia is a characteristic of solid tumors that can lead to tumor angiogenesis and early metastasis, and addressing hypoxia presents tremendous challenges. In this work, a nanomedicine based on oxygen-absorbing perfluorotributylamine (PFA) and the bioreductive prodrug tirapazami...

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Bibliographic Details
Main Authors: Hongfang Chen, You Fu, Kai Feng, Yifan Zhou, Xin Wang, Haohan Huang, Yan Chen, Wenhao Wang, Yuanjing Xu, Haijun Tian, Yuanqing Mao, Jinwu Wang, Zhiyuan Zhang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Nanobiotechnology
Subjects:
Metal-organic framework (MOF)
Tumor hypoxia
Photothermal therapy (PTT)
Osteosarcoma
Online Access:https://doi.org/10.1186/s12951-021-01013-0

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