Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development
Cellular plasticity refers to the ability of cell fates to be reprogrammed given the proper signals, allowing for dedifferentiation or transdifferentiation into different cell fates. In vitro, this can be induced through direct activation of gene expression, however this process does not naturally o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00781/full |
| _version_ | 1818188958961500160 |
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| author | Sophia Ka Yan Ma Andy Shing Fung Chan Aqsa Rubab Wilson Cheuk Wing Chan Wilson Cheuk Wing Chan Wilson Cheuk Wing Chan Danny Chan Danny Chan |
| author_facet | Sophia Ka Yan Ma Andy Shing Fung Chan Aqsa Rubab Wilson Cheuk Wing Chan Wilson Cheuk Wing Chan Wilson Cheuk Wing Chan Danny Chan Danny Chan |
| author_sort | Sophia Ka Yan Ma |
| collection | DOAJ |
| description | Cellular plasticity refers to the ability of cell fates to be reprogrammed given the proper signals, allowing for dedifferentiation or transdifferentiation into different cell fates. In vitro, this can be induced through direct activation of gene expression, however this process does not naturally occur in vivo. Instead, the microenvironment consisting of the extracellular matrix (ECM) and signaling factors, directs the signals presented to cells. Often the ECM is involved in regulating both biochemical and mechanical signals. In stem cell populations, this niche is necessary for maintenance and proper function of the stem cell pool. However, recent studies have demonstrated that differentiated or lineage restricted cells can exit their current state and transform into another state under different situations during development and regeneration. This may be achieved through (1) cells responding to a changing niche; (2) cells migrating and encountering a new niche; and (3) formation of a transitional niche followed by restoration of the homeostatic niche to sequentially guide cells along the regenerative process. This review focuses on examples in musculoskeletal biology, with the concept of ECM regulating cells and stem cells in development and regeneration, extending beyond the conventional concept of small population of progenitor cells, but under the right circumstances even “lineage-restricted” or differentiated cells can be reprogrammed to enter into a different fate. |
| first_indexed | 2024-12-11T23:35:12Z |
| format | Article |
| id | doaj.art-d93825d5d2244fe5a81f15197f7262f6 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T23:35:12Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d93825d5d2244fe5a81f15197f7262f62022-12-22T00:45:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-08-01810.3389/fcell.2020.00781567065Extracellular Matrix and Cellular Plasticity in Musculoskeletal DevelopmentSophia Ka Yan Ma0Andy Shing Fung Chan1Aqsa Rubab2Wilson Cheuk Wing Chan3Wilson Cheuk Wing Chan4Wilson Cheuk Wing Chan5Danny Chan6Danny Chan7School of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaDepartment of Orthopedics Surgery and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, ChinaThe University of Hong Kong Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, ChinaSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong, ChinaThe University of Hong Kong Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, ChinaCellular plasticity refers to the ability of cell fates to be reprogrammed given the proper signals, allowing for dedifferentiation or transdifferentiation into different cell fates. In vitro, this can be induced through direct activation of gene expression, however this process does not naturally occur in vivo. Instead, the microenvironment consisting of the extracellular matrix (ECM) and signaling factors, directs the signals presented to cells. Often the ECM is involved in regulating both biochemical and mechanical signals. In stem cell populations, this niche is necessary for maintenance and proper function of the stem cell pool. However, recent studies have demonstrated that differentiated or lineage restricted cells can exit their current state and transform into another state under different situations during development and regeneration. This may be achieved through (1) cells responding to a changing niche; (2) cells migrating and encountering a new niche; and (3) formation of a transitional niche followed by restoration of the homeostatic niche to sequentially guide cells along the regenerative process. This review focuses on examples in musculoskeletal biology, with the concept of ECM regulating cells and stem cells in development and regeneration, extending beyond the conventional concept of small population of progenitor cells, but under the right circumstances even “lineage-restricted” or differentiated cells can be reprogrammed to enter into a different fate.https://www.frontiersin.org/article/10.3389/fcell.2020.00781/fullextracellular matrixplasticitydevelopmentlimb regenerationchondrocytehypertrophic chondrocyte |
| spellingShingle | Sophia Ka Yan Ma Andy Shing Fung Chan Aqsa Rubab Wilson Cheuk Wing Chan Wilson Cheuk Wing Chan Wilson Cheuk Wing Chan Danny Chan Danny Chan Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development Frontiers in Cell and Developmental Biology extracellular matrix plasticity development limb regeneration chondrocyte hypertrophic chondrocyte |
| title | Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development |
| title_full | Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development |
| title_fullStr | Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development |
| title_full_unstemmed | Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development |
| title_short | Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development |
| title_sort | extracellular matrix and cellular plasticity in musculoskeletal development |
| topic | extracellular matrix plasticity development limb regeneration chondrocyte hypertrophic chondrocyte |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00781/full |
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