Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia
Abstract Our previous study data suggested that the synapse-associated protein 97 (SAP97) rs3915512 polymorphism is significantly related to clinical performance in schizophrenia. The cerebellum exhibits abundant expression of SAP97, which is involved with negative symptoms, cognition and emotion in...
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BMC
2023-08-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-05036-9 |
| _version_ | 1797451854485913600 |
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| author | Xusan Xu Shucun Luo Xiaoxia Wang Xia Wen Jingwen Yin Xudong Luo Bin He Chunmei Liang Susu Xiong Dongjian Zhu Dong Lv Zhun Dai Juda Lin You Li Zhixiong Lin Wubiao Chen Zebin Luo Yajun Wang Guoda Ma |
| author_facet | Xusan Xu Shucun Luo Xiaoxia Wang Xia Wen Jingwen Yin Xudong Luo Bin He Chunmei Liang Susu Xiong Dongjian Zhu Dong Lv Zhun Dai Juda Lin You Li Zhixiong Lin Wubiao Chen Zebin Luo Yajun Wang Guoda Ma |
| author_sort | Xusan Xu |
| collection | DOAJ |
| description | Abstract Our previous study data suggested that the synapse-associated protein 97 (SAP97) rs3915512 polymorphism is significantly related to clinical performance in schizophrenia. The cerebellum exhibits abundant expression of SAP97, which is involved with negative symptoms, cognition and emotion in schizophrenia. As functional dysconnectivity with the cortical-subcortical-cerebellar circuitry has been widely shown in patients with schizophrenia, cortical-subcortical-cerebellar dysconnectivity can therefore be considered a possible intermediate phenotype that connects risk genes with schizophrenia. In this study, resting-state functional magnetic resonance imaging (fMRI) was applied to evaluate whether the SAP97 rs3915512 polymorphism changes cortical/subcortical-cerebellar resting-state functional connectivity (RSFC) in 104 Han Chinese subjects (52 first-episode schizophrenia (FES) patients and 52 matched healthy controls (HCs)). To examine RSFC between cortical/subcortical regions and the cerebellum, a ROI (region of interest)-wise functional connectivity analysis was conducted. The association between abnormal cortical/subcortical-cerebellar connectivity and clinical manifestation was further assessed in FES patients with different genotypes. The interactive effect of disease and genotype on RSFC was found between the frontal gyrus (rectus) and cerebellum. A positive correlation was suggested between RSFC in the cerebellum and the hostility scores in FES patients with the A allele, and no correlation was found in FES patients with the TT genotype. The current findings identified that SAP97 may be involved in the process of mental symptoms in FES patients via cerebellar connectivity depending on the rs3915512 polymorphism genotype. |
| first_indexed | 2024-03-09T15:00:22Z |
| format | Article |
| id | doaj.art-d93831ffd78d44f39fe4eb02fd740134 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-09T15:00:22Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-d93831ffd78d44f39fe4eb02fd7401342023-11-26T13:56:28ZengBMCBMC Psychiatry1471-244X2023-08-012311710.1186/s12888-023-05036-9Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophreniaXusan Xu0Shucun Luo1Xiaoxia Wang2Xia Wen3Jingwen Yin4Xudong Luo5Bin He6Chunmei Liang7Susu Xiong8Dongjian Zhu9Dong Lv10Zhun Dai11Juda Lin12You Li13Zhixiong Lin14Wubiao Chen15Zebin Luo16Yajun Wang17Guoda Ma18Institute of Neurology, Affiliated Hospital of Guangdong Medical UniversityDepartment of Radiology, Affiliated Hospital of Guangdong Medical UniversityInstitute of Neurology, Affiliated Hospital of Guangdong Medical UniversityInstitute of Neurology, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityInstitute of Neurology, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityInstitute of Neurology, Affiliated Hospital of Guangdong Medical UniversityDepartment of Psychiatry, Affiliated Hospital of Guangdong Medical UniversityDepartment of Radiology, Affiliated Hospital of Guangdong Medical UniversityDepartment of Radiology, Affiliated Hospital of Guangdong Medical UniversityMaternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical UniversityInstitute of Neurology, Affiliated Hospital of Guangdong Medical UniversityAbstract Our previous study data suggested that the synapse-associated protein 97 (SAP97) rs3915512 polymorphism is significantly related to clinical performance in schizophrenia. The cerebellum exhibits abundant expression of SAP97, which is involved with negative symptoms, cognition and emotion in schizophrenia. As functional dysconnectivity with the cortical-subcortical-cerebellar circuitry has been widely shown in patients with schizophrenia, cortical-subcortical-cerebellar dysconnectivity can therefore be considered a possible intermediate phenotype that connects risk genes with schizophrenia. In this study, resting-state functional magnetic resonance imaging (fMRI) was applied to evaluate whether the SAP97 rs3915512 polymorphism changes cortical/subcortical-cerebellar resting-state functional connectivity (RSFC) in 104 Han Chinese subjects (52 first-episode schizophrenia (FES) patients and 52 matched healthy controls (HCs)). To examine RSFC between cortical/subcortical regions and the cerebellum, a ROI (region of interest)-wise functional connectivity analysis was conducted. The association between abnormal cortical/subcortical-cerebellar connectivity and clinical manifestation was further assessed in FES patients with different genotypes. The interactive effect of disease and genotype on RSFC was found between the frontal gyrus (rectus) and cerebellum. A positive correlation was suggested between RSFC in the cerebellum and the hostility scores in FES patients with the A allele, and no correlation was found in FES patients with the TT genotype. The current findings identified that SAP97 may be involved in the process of mental symptoms in FES patients via cerebellar connectivity depending on the rs3915512 polymorphism genotype.https://doi.org/10.1186/s12888-023-05036-9SchizophreniaSAP97Rs3915512Resting-state functional connectivityCerebellum |
| spellingShingle | Xusan Xu Shucun Luo Xiaoxia Wang Xia Wen Jingwen Yin Xudong Luo Bin He Chunmei Liang Susu Xiong Dongjian Zhu Dong Lv Zhun Dai Juda Lin You Li Zhixiong Lin Wubiao Chen Zebin Luo Yajun Wang Guoda Ma Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia BMC Psychiatry Schizophrenia SAP97 Rs3915512 Resting-state functional connectivity Cerebellum |
| title | Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia |
| title_full | Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia |
| title_fullStr | Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia |
| title_full_unstemmed | Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia |
| title_short | Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia |
| title_sort | genetic contribution of synapse associated protein 97 to cerebellar functional connectivity changes in first episode schizophrenia |
| topic | Schizophrenia SAP97 Rs3915512 Resting-state functional connectivity Cerebellum |
| url | https://doi.org/10.1186/s12888-023-05036-9 |
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