Pesticides and Parkinson’s disease: A potential hazard in agricultural communities
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder. Its pathogenesis is related to both genetic and environmental factors. Current evidence suggests that pesticide exposure is one of the risk factors of PD. In this review, we summarize four molecular mechanisms of pesticide-induced P...
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| Format: | Article |
| Language: | English |
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Southwest Respiratory and Critical Care Chronicles
2017-07-01
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| Series: | Southwest Respiratory and Critical Care Chronicles |
| Subjects: | |
| Online Access: | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/406 |
| _version_ | 1818040407812997120 |
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| author | Smathorn Thakolwiboon Parunyou Julayanont Doungporn Ruthirago |
| author_facet | Smathorn Thakolwiboon Parunyou Julayanont Doungporn Ruthirago |
| author_sort | Smathorn Thakolwiboon |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a prevalent neurodegenerative disorder. Its pathogenesis is
related to both genetic and environmental factors. Current evidence suggests that pesticide
exposure is one of the risk factors of PD. In this review, we summarize four molecular
mechanisms of pesticide-induced PD with supportive evidences from both laboratory and
epidemiological studies. Rotenone is the first pesticide reported to be associated with PD by
inhibiting complex I of mitochondrial electron transport chain. Paraquat, a commonly-used
herbicide in some countries, is an oxidative stressor causing dopaminergic neuronal loss which
contributes to the pathogenesis of PD. The ubiquitin-proteasome system (UPS) and aldehyde
dehydrogenase (ALDH) inhibitors cause unwanted proteins (especially alpha-synuclein) and
3,4-dihydroxyphenylacetaldehyde (DOPAL) accumulation leading to dopaminergic neuronal
apoptosis. In addition, exposure to different pesticides affecting different mechanisms may
have synergistic effects in increasing risk of PD. Protective glove use, the amount of fat intake,
and neuroprotective agents are reported to have disease modification effects for pesticideassociated
PD. |
| first_indexed | 2024-12-10T08:14:03Z |
| format | Article |
| id | doaj.art-d9388ab4dd044cdeab71badb5e8f4021 |
| institution | Directory Open Access Journal |
| issn | 2325-9205 |
| language | English |
| last_indexed | 2024-12-10T08:14:03Z |
| publishDate | 2017-07-01 |
| publisher | Southwest Respiratory and Critical Care Chronicles |
| record_format | Article |
| series | Southwest Respiratory and Critical Care Chronicles |
| spelling | doaj.art-d9388ab4dd044cdeab71badb5e8f40212022-12-22T01:56:31ZengSouthwest Respiratory and Critical Care ChroniclesSouthwest Respiratory and Critical Care Chronicles2325-92052017-07-01520606710.12746/swrccc.v5i20.406335Pesticides and Parkinson’s disease: A potential hazard in agricultural communitiesSmathorn Thakolwiboon0Parunyou Julayanont1Doungporn Ruthirago2Department of Neurology, Texas Tech University Health Sciences Center, Lubbock TXDepartment of Neurology, Texas Tech University Health Sciences Center, Lubbock TXDepartment of Neurology, Texas Tech University Health Sciences Center, Lubbock TXParkinson’s disease (PD) is a prevalent neurodegenerative disorder. Its pathogenesis is related to both genetic and environmental factors. Current evidence suggests that pesticide exposure is one of the risk factors of PD. In this review, we summarize four molecular mechanisms of pesticide-induced PD with supportive evidences from both laboratory and epidemiological studies. Rotenone is the first pesticide reported to be associated with PD by inhibiting complex I of mitochondrial electron transport chain. Paraquat, a commonly-used herbicide in some countries, is an oxidative stressor causing dopaminergic neuronal loss which contributes to the pathogenesis of PD. The ubiquitin-proteasome system (UPS) and aldehyde dehydrogenase (ALDH) inhibitors cause unwanted proteins (especially alpha-synuclein) and 3,4-dihydroxyphenylacetaldehyde (DOPAL) accumulation leading to dopaminergic neuronal apoptosis. In addition, exposure to different pesticides affecting different mechanisms may have synergistic effects in increasing risk of PD. Protective glove use, the amount of fat intake, and neuroprotective agents are reported to have disease modification effects for pesticideassociated PD.http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/406pesticides, Parkinson, Parkinsonism, agriculture |
| spellingShingle | Smathorn Thakolwiboon Parunyou Julayanont Doungporn Ruthirago Pesticides and Parkinson’s disease: A potential hazard in agricultural communities Southwest Respiratory and Critical Care Chronicles pesticides, Parkinson, Parkinsonism, agriculture |
| title | Pesticides and Parkinson’s disease: A potential hazard in agricultural communities |
| title_full | Pesticides and Parkinson’s disease: A potential hazard in agricultural communities |
| title_fullStr | Pesticides and Parkinson’s disease: A potential hazard in agricultural communities |
| title_full_unstemmed | Pesticides and Parkinson’s disease: A potential hazard in agricultural communities |
| title_short | Pesticides and Parkinson’s disease: A potential hazard in agricultural communities |
| title_sort | pesticides and parkinson s disease a potential hazard in agricultural communities |
| topic | pesticides, Parkinson, Parkinsonism, agriculture |
| url | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/406 |
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